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Resources results for "il-1%CE%B2"

  • Products (274)
  • Resources (1836)

Erk Antibody Comparison Table

Compare Cell Signaling Technology's Erk antibodies against one another to determine optimal applications

Organelle Markers

Organelle markers for immunofluorescence analysis from CST Cell Signaling Technology

Cytokines and Inflammation

Products and Related Resources for Cytokines and Inflammation SARS-CoV-2 Research

Jak/Stat Utilization Table

The Jak/Stat Utilization Table displays the combinatorial use of tyrosine kinases and Stat proteins in cytokine/growth factor signaling.

Resources

We have not tested our Sox2 (D6D9) XP® Rabbit mAb #3579 for cross-reactivity with other SOX family transcription factors. However, sequence alignments have been done between the antigen used to produce the Sox2 (D6D9) XP® Rabbit mAb #3579 and the B1 Sox proteins (i.e., SOX1 and SOX3, which includes SOX2) and the B2 Sox proteins (i.e., SOX14 and SOX21). Because there is no significant sequence identity between the sequences, we do not foresee any cross-reactivity with SOX1, SOX3, SOX14, or SOX21.
 

ChIP Validated Antibodies and Primer Pairs

SimpleChIP Kits and Antibodies validated in-house by our antibody development scientists correlated to positive and negative control primers.

Adaptive Immune Response

Products and Related Resources for Adaptive Immune Response SARS-CoV-2 Research

TIR Protein Domain

A scientific resource for the TIR protein domain containing information on structure, function, and binding in TLR Signaling.

Fibrosis

Products and Related Resources for Fibrosis SARS-CoV-2 Research

Rheumatoid Arthritis Pathogenesis Signaling Pathway

Expert-reviewed interactive diagram of Rheumatoid Arthritis Pathogenesis and relevant antibodies for studying targets associated with the autoimmune disease.

TRAF Protein Domain

A scientific resource for the TRAF protein domain containing information on structure, function, and domain binding in TNFR Signaling.

Inflammasome Signaling

The Inflammasome pathway is essential for the innate immune response, but it can also contribute to the onset of a number of diseases. Learn more here.

Acquiring Senescence

Cellular senescence is characterized by irreversible cell-cycle arrest in combination with a distinct secretory phenotype and expanded lysosomes in response to stress. Senescent cells accumulate in tissues during aging, and various markers of senescence

Type I Interferon and Viral Restriction Factors

Products and Related Resources for Type I Interferon and Viral Restriction Factors SARS-CoV-2 Research

Resources

CIP/Lambda Phosphatase Treatment of Cell Lysates:

1) Wash cells 2X with ice-cold PBS.

2) Add cold 1X cell lysis buffer that does not include phosphatase inhibitors [1-2 E7 cells per ml or 0.4ml per 10 cm plate (80-90% confluent)]. Our cell lysis buffer is prepared as follows:

20 mM Tris-HCl (pH 7.5)
150 mM NaCl
1 mM Na2EDTA
1 mM EGTA
1% Triton
1 ug/ml leupeptin
1mM PMSF

3) Add 20ul Quick CIP (NEB #M0525; https://www.neb.com/products/m0525-quick-cip#Product%20Information) per 400ul of cell extract.

4) Incubate with Quick CIP at 37C for 1 hour.

5) Add 20ul lambda protein phosphatase (CST

Resources

No materials of animal origin are used in the production of our Human IL-22 Recombinant Protein #74808. Therefore, additional testing for infectious material is not relevant.

Necroptosis and Pyroptosis Add to Our Understanding of Regulated Cell Death

These markers can be used to study necroptosis and pyroptosis, forms of regulated necrotic cell death that share morphological features with necrosis.

Angiogenesis

Expert-reviewed interactive pathway providing a current overview of angiogenesis pathways and links to products by Cell Signaling Technology.

PTMScan® Discovery in Translational Research (A Case Study)

PTMScan Discovery in Translational Research (A Case Study)

Overview of Cell Death

Apoptosis is a type of programmed cell death that occurs normally throughout the lifespan and can also occur in response to harmful stimuli. Apoptotic cells are identified by their altered morphology, caspase activation, and the presence of damaged DNA.

Introducing Validated Antibodies for Simple Western–An Automated Capillary Electrophoresis Immunoassay

CST antibodies have been validated for Simple Western, the only platform on the market that provides a fully automated western blotting workflow.

Jak/Stat: IL-6 Receptor Signaling

Study the IL-6 pathway and its impact on inflammation and immune regulation. Delve into the intricacies of this signaling cascade. Click here.

Overview of Immunology

The immune system is composed of tissues, cells, and molecules whose primary function is to detect, respond to, and eliminate pathogens and transformed cells.

Neuroinflammation in Neurodegenerative Diseases

Neuroinflammation is the activation of an immune response in the CNS by the microglia and astrocytes. While not linked mechanistically to neurodegenerative diseases, neuroinflammation is associated with the progression of Alzheimer’s disease, Parkinson’s

10 Must-have Markers for Senescence Research

Interested in studying senescence? Understanding cell cycle arrest is critical to many fields of research, including development, aging, and cancer.

Neuroinflammation in Neurodegenerative Diseases

Chronic neuroinflammation is associated with neurodegenerative diseases like Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis, and others.

Resources

When performing In-Cell Western assays with DyLight 680-conjugated secondary antibodies, we recommend using either Hoechst 33342 or DAPI as a nuclear dye. DRAQ5 cannot be used because the emission spectra of DRAQ5 and DyLight 680 overlap, and the signal produced by each dye cannot be distinguished.

Still in the Dark: AMD Patients Wait for Answers

Our summary of recent findings published in Nature, which indicate that non-performing antibodies were used in many recent macular degeneration studies.

Toll-like Receptor Signaling

Expert-reviewed interactive pathway providing a current overview of TLR signaling.

What is Senescence?

Cellular senescence is defined by permanent cell cycle arrest. Senescent cells accumulate with age and contribute to normal aging and age-related disorders