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Interact with this diagram showing the epigenetic writers and erasers of histone H2A, histone H2B, and Histone H4, including the involvement of acetyltransferases, deacetylases, methyltransferases, demethylases and kinases.
The Ubiquitin Ligase Table provides a comprehensive list of E3 ubiquitin ligases along with their substrates and corresponding PubMed reference(s).
SimpleChIP Kits and Antibodies validated in-house by our antibody development scientists correlated to positive and negative control primers.
The Histone Modification Table provides a referenced list of many known histone modifications, associated modifying enzymes, and proposed functions.
Mass spectrometry is a highly sensitive technology used to study proteins and their PTMs in a sample on a large scale.
UbiScan® - Ubiquitination Proteomics
PTMScan® Sumoylation Remnant Motif Kit - SUMOylation Proteomics
Streamline Targeted Protein Degradation Drug Discovery with specific, application-validated antibodies and industry-leading proteomic services.
A scientific resource for the UBA protein domain containing information on structure, function, and domain binding to ubiquitin in protein degradation pathways.
Proteomics can help elucidate mitochondrial homeostasis and dysfunction, inflammasome activation, and the role of parkin in Parkinson's disease.
Expert-reviewed interactive pathway providing a current overview of protein ubiquitination and proteasome degradation, as well as links to products from Cell Signaling Technology.
A scientific resource for the GLUE protein domain containing information on structure, function, and binding to phospholipids in the regulation of vesicle trafficking.
Study the ubiquitin proteasome pathway and its critical role in protein degradation and cellular homeostasis. Expert reviewed pathways.
Expert-reviewed interactive pathway providing a current overview of Cell Cycle G1/S Checkpoint Signaling.
Mitophagy is a well-studied example of selective autophagy. This post explores mitophagy functions and the consequence of excessive or inadequate mitophagy
Matthew Stokes, Ph.D., and Christopher Rose, Ph.D. introduce Cell Signaling Technology’s PTMScan® method and provide a demonstration of its applications.
The PI3K / Akt Substrates Table provides a comprehensive list of demonstrated downstream targets of Akt phosphorylation.
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
Explore the intricate Wnt Beta Catenin pathway & its role in cell development and disease. Learn more about the signaling cascade of this crucial pathway.
Fostering mentorship, application-based learning, and a love of science are all part of the mission of the CST internship program. Students interning with us are partnered with CST Mentors.
A scientific resource for the MIU protein domain containing information on structure, function, and domain binding to ubiquitin during vesicle trafficking.
Cell Signaling Technology pathways by research area
A scientific resource for the UEV protein domain containing information on structure, function, and domain binding to ubiquitin.
A scientific resource for the UIM protein domain containing information on structure, function, and domain binding to ubiquitin.
What if an antibody could identify a PTM, regardless of the flanking amino acid sequence? This innovative idea is the basis of CST's PTMScan product line.
The Ubiquitin (E4I2J) Rabbit mAb #43124 is the preferred antibody for detecting free-ubiquitin. Ubiquitin (P37) Antibody #58395 is also an option for the detection of free-ubiquitin, while Ubiquitin (P4D1) Mouse mAb #3936 and Ubiquitin (E6K4Y) XP® Rabbit mAb #20326 detect free-ubiquitin weakly. To increase the signal for free-ubiquitin (and all ubiquitin levels), the membrane can be boiled for 30 minutes or autoclaved for 30 minutes on a wet cycle prior to the blocking step.
A scientific resource for the HECT protein domain containing information on structure, function, and domain binding in ubiquitin-mediated protein degradation.
Trim-Away is an antibody-based method for protein knockdown that can be easily implemented for faster results without additional training or equipment.
A scientific resource for the GAT protein domain containing information on structure, function, and domain binding to ubiquitin and GTP-bound ARF.
Necrosis has been classically defined as an unprogrammed form of cell death that occurs in response to overwhelming chemical or physical insult.
