Basket Updated
0
Items added
Explore the intricate Wnt Beta Catenin pathway & its role in cell development and disease. Learn more about the signaling cascade of this crucial pathway.
Overview of Adhesion and Extracellular Matrix signaling networks, antibodies and related reagents, interactive pathway diagrams, and technical resources.
List of publications based on primary research done by the Cancer Research Group at CST (2002-2013).
A number of growth factors and cytokines can induce an Epithelial-Mesenchymal Transition (EMT) in tumor cells.
The Ubiquitin Ligase Table provides a comprehensive list of E3 ubiquitin ligases along with their substrates and corresponding PubMed reference(s).
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
SimpleChIP® Plus Sonication Chromatin Immunoprecipitation Protocol (Magnetic Beads): easy to follow directions describing the step by step experimental procedure
Amyloid beta is a protein fragment of the amyloid precursor protein, and is the major component of Alzheimer’s disease plaques.
Expert-reviewed signaling pathway providing a current overview of adherens junction dynamics and links to products by Cell Signaling Technology.
Expert-reviewed diagram providing a current overview of the Mechanisms of Fibrosis pathway with references to its role in adhesion
Cellular senescence is characterized by irreversible cell-cycle arrest in combination with a distinct secretory phenotype and expanded lysosomes in response to stress. Senescent cells accumulate in tissues during aging, and various markers of senescence
We’ve put together a starter’s guide on the cellular mechanisms that drive neurodegeneration in diseases such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington’s disease.
Neuroinflammation is a condition observed in the central nervous system (CNS) in response to infection, toxic metabolites, traumatic injury, or autoimmunity.
A journal club article elucidating the mechanisms of beta cell failure leading to type 2 diabetes.
Find Pathways and Diagrams By Disease Area
Products and Related Resources for Fibrosis SARS-CoV-2 Research
A scientific resource for the ADF protein domain containing information on structure, function, and binding to monomeric and filamentous actin.
Senescence has been linked to a general decline in tissue function during aging as well as a number of disease states.
Western Blotting troubleshooting guide for easy to solve high and low background issues.
Overview of stem cell markers, lineage markers, development and differentiation signaling networks at Cell Signaling Technology.
Discover the TGF Beta signaling pathway and impact on cell growth & tissue homeostasis. Learn here the mechanisms behind this vital signaling cascade.
Cancer cells can revert to a pre-differentiated, stem-cell-like phenotype, allowing uninhibited cellular division and other metabolic adaptations that enable survival in adverse conditions. Two key signaling components enable replicative immortality, Hippo and WNT.
Neurodegeneration refers to disorders of the CNS that lead to loss of neurons or glia, and is associated with age-related diseases, autoimmune attacks on the nervous system, or genetic mutations that affect the heath of CNS cells.
Resources include signaling pathways, antibodies and companion products, research overviews, technical resources, and recent review articles.
A scientific resource for the ARM protein domain containing information on structure, function, and domain binding.
Summary of human oncogenes and tumor suppressor genes sorted by signaling pathway.
Unfortunately, we are not aware if any of our amyloid-beta antibodies will detect the alpha-oligomer of the amyloid-beta protein.
Discuss the mechanisms and control of antiproliferation signaling from cytokines such as transforming growth factor beta (TGF-β) and their role in cancer progression
A scientific resource for the MH2 protein domain containing information on structure, function, and domain binding to phospho-serine motifs during TGF-beta signaling.