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Information and case study data for the PTMScan Direct Tyrosine Kinases Service from Cell Signaling Technology.
The Jak/Stat Utilization Table displays the combinatorial use of tyrosine kinases and Stat proteins in cytokine/growth factor signaling.
Products and Related Resources for Type I Interferon and Viral Restriction Factors SARS-CoV-2 Research
Products and Related Resources for Cytokines and Inflammation SARS-CoV-2 Research
Expert-reviewed interactive pathway providing a current overview of ErbB/HER Signaling.
Kinase-disease associations table showing kinases, kinase groups, disease types, and the molecular biology basis for disease.
The Phospho-Tyrosine Mouse mAb (P-Tyr-100) #9411 is a mouse mAb from a single clone, whereas the Phospho-Tyrosine (P-Tyr-1000) MultiMab™ Rabbit mAb mix #8954 is a mix of rabbit mAbs from multiple clones. The p-Tyr designations, including “p-Tyr-100” and “p-Tyr-1000,” are a naming convention to allow customers to readily differentiate between the multiple products that we offer against this motif. The designations are not meant to suggest differences in quality or performance. In general, #8954 is a stronger antibody compared to #9411, and using our PTMScan® technology, we have found that #8954 detects more unique phosphorylated peptides than #9411. Both products are highly specific to phosphorylated tyrosine residues.
Custom synthesized, isotope-labeled AQUA peptides for validating and quantifying protein markers and post-translational modifications from Cell Signaling Technology.
A scientific resource for the PTB protein domain containing information on structure, function, and domain binding to phospho-tyrosine motifs.
PTMScan Technology enables biomarker discovery and signaling regulation by combining enrichment of post-translational modifications with mass spectrometry.
Illustration of Motif Antibody Coverage
Click here to read about the phospholipase C pathway and its role in cellular signaling and regulation.
Explore the G protein coupled receptor signaling pathway and its diverse roles in cellular communication. Read more here.
PTMScan Motif Antibody Kits from Cell Signaling Technology
A scientific resource for the SH2 protein domain containing information on structure, function, and domain binding to phospho-tyrosine motifs.
PhosphoScan® Phosphorylation Proteomics
PTMScan Motif Antibodies and Kits, for customers who purchase a license and would like to perform PTMScan Proteomics in-house.
This video introduces PTMScan technology, a platform for the enrichment of post-translational modifications (PTMs) in mass spectrometry-based proteomics studies.
A categorical list of protein domain resources by Cell Signaling Technology. Each resource contains specific domain structure, function, and binding information.
A video tutorial illustrating the methodology behind PTMScan Technology and an example of its use in a recent phosphoproteomic study authored by scientists from CST.
Control peptides can be used to ensure reproducibility in proteomics experiments conducted with PTMScan.
Case Study 1: Exceptional Specificity of XP Monoclonal Antibodies pertaining to eXceptional Monoclonal Technology (XMT) from Cell Signaling Technology.
To study pathways regulated by nitrotyrosine, CST offers two recombinant monoclonal antibodies against the same PTM for WB and proteomic applications.
List of publications based on primary research done by the Cancer Research Group at CST (2002-2013).
The Kinase Library can determine the kinases likely to phosphorylate any given motif. Learn about the research enabling this phosphoproteomics revolution.
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.