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Information and case study data for the PTMScan Direct Tyrosine Kinases Service from Cell Signaling Technology.
Information and case study data for the PTMScan Direct PI3K/Akt Service offered by CST, which allows for targeted screening of 105 proteins within the Akt pathway.
The family of Trk receptor tyrosine kinases consists of TrkA, TrkB, and TrkC. While the sequence of these family members is highly conserved, they are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3.
TrkA is a highly glycosylated protein. Therefore, its size can differ depending on the amount of glycosylation present. Un-glycosylated TrkA is 87 KDa, so this is likely what the 90kDa band is on the blot.
A scientific resource for the PTB protein domain containing information on structure, function, and domain binding to phospho-tyrosine motifs.
A scientific resource for the 14-3-3 protein domain containing information on structure, function, and binding to phospho-serine and phospho-threonine motifs.
Kinase-disease associations table showing kinases, kinase groups, disease types, and the molecular biology basis for disease.
Jak and cytokine receptor mutations found in various cancers, along with the corresponding PubMed reference(s).
Information and case study data for the PTMScan Direct Cell Cycle and DNA Damage Service offered by CST.
Expert-reviewed interactive pathway providing a current overview of ErbB/HER Signaling.
Find validated CST® matched antibody pairs and streamline the development of your High-Throughput ELISA-Like Immunoassays for screening.
Identification of ALK and ROS1 fusion proteins in non-small cell lung cancer (NSCLC) at Cell Signaling Technology.
The PI3K / Akt Substrates Table provides a comprehensive list of demonstrated downstream targets of Akt phosphorylation.
The ESC and Lineage Markers diagram provides an overview of ESC differentiation along lineage-specific pathways and links to products from CST.
Guest blogger Dr Gregory discusses research to define the epitranscriptome, including modifications that increase tRNA stability and prevent degradation.
Resources for the study of Translational Control, Protein Synthesis, and RNA Regulation including antibodies and associated reagents and interactive pathway diagrams.
Cell Signaling Technology, Inc. (CST) is ISO 9001:2008 certified for the design, development, and production of monoclonal antibodies (mAbs).
Highlighted common pluripotency markers with a brief description of their expression from Cell Signaling Technology
Learn more about stem cell pathways and the transcription factors Oct-4, Sox2, and Nanog are essential for maintaining the pluripotent state of stem cells.
Expert-reviewed interactive pathway providing a current overview of Regulation of eIF2.
Overview of stem cell markers, lineage markers, development and differentiation signaling networks at Cell Signaling Technology.
Cell Signaling Technology, Inc. (CST) of Danvers, MA, announced today that it has introduced a highly specific PD-L1 rabbit monoclonal antibody (mAb).
We have no specific tips for using FACS-isolated cells in CUT&RUN experiments. Like a cultured cell suspension, if your isolated cells are in less than 40ul PBS, you can move directly to Concanavalin A bead binding by adding wash buffer for a total of 100ul per reaction. Otherwise, you need to either spin the cells and remove some of the PBS or add wash buffer and Concanavalin A beads proportionally based on the volume of PBS you have in your sorted cell sample. In our experience, the Concanavalin A beads do not bind to cells in the pure PBS environment.
Cell Signaling Technology, a leading provider of antibodies, kits and services, announced today that it has won two Life Science Industry Awards® for "Best Antibodies" and "Most Useful Website."
Dako and Cell Signaling Technology (CST) today announced that they have entered into a strategic partnership to supply antibodies for use in Dako-branded companion diagnostics products.
Study the ubiquitin proteasome pathway and its critical role in protein degradation and cellular homeostasis. Expert reviewed pathways.
Learn how RNA-binding proteins influence RNA regulation and epitranscriptomics and contribute to the progression of a variety of diseases.
List of publications based on primary research done by the Cancer Research Group at CST (2002-2013).
A chronological listing of case studies and peer-reviewed publications utilizing PTMScan proteomic technology developed by Cell Signaling Technology.