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Angiogenesis, the formation of new blood vessels from pre-existing blood vessels, plays a key role in tumorigenesis.
Overview of Angiogenesis antibodies & related reagents, interactive pathway diagrams, and other technical resources.
Expert-reviewed interactive pathway providing a current overview of angiogenesis pathways and links to products by Cell Signaling Technology.
Our VEGF Receptor 2 antibodies, i.e., #2472, #2479, and #9698, recognize total VEGFR2, which includes any post-translationally modified versions of the protein. Therefore, because VEGFR2 is a glycoprotein and glycosylation slows the target's migration on a SDS-PAGE gel, two bands are detected that represent the modified (glycosylated) and the unmodified (non-glycosylated) forms of VEGFR2.
Specific Aims set the stage for your grant proposal and are often considered the most important part, so make sure you're concisely conveying your goals.
Catalog numbers in tabular format for control cell extracts and proteins with links to product pages.
Cancer cells stimulate the growth of blood vessels to supply nutrients to tumors. Angiogenesis is the formation of new blood vessels from pre-existing blood vessels. This plays an important role in tumor growth.
The ESC and Lineage Markers diagram provides an overview of ESC differentiation along lineage-specific pathways and links to products from CST.
Learn here about the HIF-1 signaling pathway and its impact on oxygen homeostasis and cellular adaptation. Click here.
Senescence is the irreversible arrest of proliferation in response to a variety of cellular stressors. This state is associated with changes in intracellular signaling pathways. Learn more.
In response to a variety of environmental factors, cells may permanently cease proliferation and enter a state known as cellular senescence.
Molecular oxygen is an essential element for metazoan life. Among its many roles, it functions as the final electron acceptor (oxidizing agent) during oxidative phosphorylation, a metabolic chain-reaction that generates energy in the form of ATP. HIF-1 alpha
Information and case study data for the PTMScan Direct Cell Cycle and DNA Damage Service offered by CST.
Find validated CST® matched antibody pairs and streamline the development of your High-Throughput ELISA-Like Immunoassays for screening.
The PI3K / Akt Substrates Table provides a comprehensive list of demonstrated downstream targets of Akt phosphorylation.
Streamline your oncology therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
Information and case study data for the PTMScan Direct Tyrosine Kinases Service from Cell Signaling Technology.
Kinase-disease associations table showing kinases, kinase groups, disease types, and the molecular biology basis for disease.
Learn more about commonly used chemical modulators to study cellular physiology and biology.
Information and case study data for the PTMScan Direct PI3K/Akt Service offered by CST, which allows for targeted screening of 105 proteins within the Akt pathway.
Researchers are still working hard to develop effective treatments for SARS-CoV-2 and COVID-19.
A list of important CD markers that includes links to PhosphoSitePlus, Uniprot, and products from Cell Signaling Technology.
List of publications based on primary research done by the Cancer Research Group at CST (2002-2013).
The Histone Modification Table provides a referenced list of many known histone modifications, associated modifying enzymes, and proposed functions.
A chronological listing of case studies and peer-reviewed publications utilizing PTMScan proteomic technology developed by Cell Signaling Technology.
Expert-reviewed interactive pathway providing a current overview of ErbB/HER Signaling.
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
The Ubiquitin Ligase Table provides a comprehensive list of E3 ubiquitin ligases along with their substrates and corresponding PubMed reference(s).