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Clustered regularly interspaced short palindromic repeats, or CRISPRs, are repetitive sequences (direct repeats) native to the prokaryote genome.
Validation using recombinant proteins or exogenous expression in a surrogate cell line can be used for targets with low levels of protein expression.
For antigenic targets where expression of the protein is very low or unknown, the use of recombinant proteins or exogenous expression in a surrogate cell line may be necessary for antibody validation.
CST Technical Support Article
Sometimes understanding complex signaling is overwhelming. Try thinking about it as the wiring on a construction site. Maybe that will help!
Testing ELISA kit lots for percent coefficient of variation (CV), signal/blank ratios, and optical density helps ensure scientific reproducibility.
Expert-reviewed interactive pathway providing a current overview of Regulation of Actin Dynamics.
Alphabetical listing of protein, pathway, and antibody acronyms, curated by Cell Signaling Technology.
Find validated CST® matched antibody pairs and streamline the development of your High-Throughput ELISA-Like Immunoassays for screening.
PD is characterized by functional loss in dopaminergic neurons, believed to be caused by disruption of proteins involved in cell quality control pathways.
The specificity of our Phospho-AMPKα (Thr172) (40H9) Rabbit mAb #2535 has been confirmed as follows:1) see the western image on the product webpage at https://www.cellsignal.com/products/primary-antibodies/phospho-ampka-thr172-40h9-rabbit-mab/2535. The specificity of #2535 has been confirmed on a binary model (i.e., on extracts from C2C12 cells, untreated or oligomycin-treated (0.5 µM). 2) shRNAPMID: 28553939 (https://pubmed.ncbi.nlm.nih.gov/28553939/) Figure 1b3) CRISPR/Cas9 PMID: 30415923 (https://pubmed.ncbi.nlm.nih.gov/30415923/) Figure 3A
Explore the ERK pathway and its role in cell proliferation and survival. Click here to read more about this critical signaling pathway.
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
Information and case study data for the PTMScan Direct Apoptosis/Autophagy Service offered by CST.
A novel study from the laboratory of Daniel Figeys begins to unravel the complexity of the microbiome of pediatric patients with Crohn’s disease.
Quit living in the past! The future of cars is electric.
PTMScan Discovery in Translational Research (A Case Study)
Information and case study data for the PTMScan Direct Tyrosine Kinases Service from Cell Signaling Technology.
Information and case study data for the PTMScan Direct Cell Cycle and DNA Damage Service offered by CST.
There's a need for new methods to diagnose and treat pancreatic cancer. Biomarkers like CA 19-9 and MUC5AC are being explored as prognosis indicators.
A chronological listing of case studies and peer-reviewed publications utilizing PTMScan proteomic technology developed by Cell Signaling Technology.
Case Study 4: Exceptional Performance of XP Monoclonal Antibodies from Cell Signaling Technology.
Case Study 3: Exceptional Reproducibility of XP Monoclonal Antibodies from Cell Signaling Technology.
Overview of Adhesion and Extracellular Matrix signaling networks, antibodies and related reagents, interactive pathway diagrams, and technical resources.
Performance characteristics of XP rabbit monoclonal antibodies from Cell Signaling Technology.
Case Study 1: Exceptional Specificity of XP Monoclonal Antibodies pertaining to eXceptional Monoclonal Technology (XMT) from Cell Signaling Technology.
Case Study 2: Exceptional Sensitivity of XP Monoclonal Antibodies pertaining to eXceptional Monoclonal Technology (XMT) from Cell Signaling Technology.
Information and case study data for the PTMScan Direct Ser/Thr Kinases Service, which allows for the targeted screening of a defined set of protein modification sites.
Information and case study data for the PTMScan Direct PI3K/Akt Service offered by CST, which allows for targeted screening of 105 proteins within the Akt pathway.