Basket Updated
0
Items added
Our Phospho-Akt (Ser473) (D9E) XP® Rabbit mAb #4060 and Phospho-Akt (Ser473) (D9W9U) Mouse mAb #12694 detect over-expressed PKC alpha and beta. Our Phospho-Akt (Ser473) (D9E) XP® Rabbit mAb #4060 also detects endogenous levels of PKC in Jurkat + CalA extract, but not in other endogenous models tested. Our Phospho-Akt (Ser473) (587F11) Mouse mAb #4051 detects over-expressed PKC alpha and beta but does not detect endogenous PKC in the models tested. Our Phospho-Akt (Ser473) (193H12) Rabbit mAb #4058 does not detect over-expressed or endogenous PKC alpha and beta.
Expert-reviewed interactive pathway providing a current overview of Regulation of eIF4E and p70 S6K.
Unfortunately, our PD-1 or PD-L1 antibodies have not been tested in neutralization assays. Therefore, we cannot guarantee their performance.
Harnessing the power of the immune system's T cells to attack and treat cancer is a promising research area that may lead to highly effective therapies.
Checkpoint inhibitors, targeted antibodies, adoptive cell therapy, and cancer vaccines are promising immunotherapies with recent therapeutic developments.
We offer 3 MitoTracker® products, MitoTracker® Green FM #9074, MitoTracker® Deep Red FM #8778 and MitoTracker® Red CMXRos #9082. MitoTracker® Deep Red FM #8778 and MitoTracker® Red CMXRos #9082 are well retained after methanol fixation as outlined in our Product Usage Information. MitoTracker® Green FM #9074, on the other hand, is only useful for live cell imaging as the dye is not well retained after fixation with aldehydes or alcohols.
Ever wonder how we validate our antibodies? It's time to pull back the curtain.
Our Phospho-Akt (Thr308) (C31E5E) Rabbit mAb #2965 detects over-expressed levels of PKCalpha and beta. It also detects endogenous levels of PKC in Jurkat + CalA extract and possibly weakly in other endogenous models tested. Our Phospho-Akt (Thr308) (L32A4) Mouse mAb #5106 and Phospho-Akt (Thr308) Antibody #9275 detect over-expressed levels of PKCalpha and beta, but do not detect endogenous PKC. Our Phospho-Akt (Thr308) (244F9) Rabbit mAb #4056 detects over-expressed levels of PKCalpha and beta and may also weakly detect endogenous PKC in Jurkat + CalA extract, but not in other endogenous models tested. Our Phospho-Akt (Thr308) (D25E6) XP Rabbit mAb #13038 does not detect over-expressed PKC and is the best choice of the Phospho-Akt (Thr308) antibodies if this is a concern.
Explore the intricate Wnt Beta Catenin pathway & its role in cell development and disease. Learn more about the signaling cascade of this crucial pathway.
Protein A predominantly binds intact IgG and does not bind denatured IgG well. It can be used in IP experiments to help avoid the potential masking of signal by denatured IgG heavy and light chain.
Expert-reviewed interactive pathway providing a current overview of protein ubiquitination and proteasome degradation, as well as links to products from Cell Signaling Technology.
The nuclear receptor signaling plays important roles in cell differentiation, proliferation, metabolism, and other physiological processes. Click here.
Cell Signaling Technology is the lucky recipient of Antibody Company of the Year and Antibody Company Succeeding in Cancer Biology awards from CiteAb.
A scientific resource for the TUDOR protein domain containing information on structure, function, and domain binding to methylated-lysine residues in chromatin remodeling.
Cancer cells reprogram their metabolic pathways to enable energy production under conditions that are disabling to most normal cells.
In this webinar, the speakers will explore how tumors exploit immune modulatory mechanisms to generate and thrive in their own immunosuppressive microenvironment, and explain how PD-1 immunotherapy stops certain cancers from turning off the anticancer immune response.
Overview of epigenetic and chromatin regulation pathways, antibodies and related reagents, interactive pathway diagrams, and technical resources for epigenetics research.
Rabbits only have one IgG isotype compared to four IgG isotypes in mice (IgG1, IgG2a, IgG2b and IgG3) and humans (IgG1, IgG2, IgG3 and IgG4). There are two types of rabbit light chains - κ and λ - with the κ light chain present as two different isotypes called K1 and K2. K1 is by far the most abundant isotype, representing between 70% and 90% of all light chains, whereas the remainder are usually a mixture of both K2 and λ-light chains. Therefore, most of our rabbit monoclonal antibodies have κ light chains.
Expert-reviewed interactive signaling pathways providing current overviews of the regulation of actin and microtubule dynamics, as well as links to products from CST.
In response to a variety of environmental factors, cells may permanently cease proliferation and enter a state known as cellular senescence.
The “eat local” trend sprung up in the early 2000s; chances are you’ve seen tote bags promoting “Buy Local,” at the grocery store checkout.
Study the intricate cell cycle pathway's regulation of cell division and proliferation. Learn more here.
Learn about antibody diversity, host species, isotypes, and how antibodies are developed for research, clinical diagnostics, and therapeutic uses.
We do not recommend our RIPA Buffer (10X) #9806 for Native PAGE as it is too stringent. Unfortunately we do not carry a buffer appropriate for Native PAGE.
Mass spectrometry-based proteomic methods like PTMScan can be applied in translational research. For example to identify novel biomarkers of disease
Expert-reviewed interactive neuroscience pathways providing current overviews of Parkinson's and Alzheimer's Disease signaling, as well as links to products from CST.
PDGF Receptor α (PDGFRa) contains a signal peptide consisting of the first 23 amino acids of the protein sequence. Mature PDGFRa does not contain this signal peptide and it is possible to see a doublet representing both forms; the lower form being the mature protein. This protein is also heavily glycosylated and thus the apparent molecular weight exceeds that of the predicted molecular weight based on amino acid sequence.
Our PTMScan assays can typically measure peptides at levels of 50 - 100 attomoles. However, this is highly dependent on the peptide and how well it electrosprays in positive ion mode. The dynamic range for our PTMScan assays is between 3-5 orders of magnitude.
Explore the complex inflammation signaling pathways. Click here to learn more and understand the molecular basis of inflammation.
Cell Signaling Technology announces the launch of SignalStar™ Multiplex IHC, a flexible spatial biology solution for up to 8-plex amplification in two days.