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Epigenetic regulation, including aberrant DNA methylation and histone modifications, have been linked to Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis.
Cellular senescence is characterized by irreversible cell-cycle arrest in combination with a distinct secretory phenotype and expanded lysosomes in response to stress. Senescent cells accumulate in tissues during aging, and various markers of senescence
Neuroinflammation is a condition observed in the central nervous system (CNS) in response to infection, toxic metabolites, traumatic injury, or autoimmunity.
Learn how PTMScan technology facilitates translational discovery, identification of disease drivers, and development of markers and treatments, as exemplified in the study of non-small cell lung cancer (NSCLC).
The complexity of the proteome makes discovery research seem like trying to find a needle in a haystack. Learn how enrichment with PTMScan decreases sample complexity and increases the likelihood that you'll find what you're looking for.
Targeted protein degradation selectively alters protein abundance by co-opting the cellular degradation machinery. The degradation tag (dTAG) system can be used for target validation and mechanistic studies.
Understand when to use immunohistochemistry (IHC) over any other technique including Immunocytochemistry, Western Blot and ELISA
Learn to ChiP
Discover the key RNA binding proteins (RBPs) in the lifecycle of messenger RNA (mRNA)
Use our protocol compatibility table to understand which immune signaling and phenotyping antibodies will work together in your multicolor flow cytometry experiment.
Immunohistochemistry is a method for studying antigen localization in tissue sections using antibodies. Learn sample preparation, labeling, & visualization.
Cell viability is a measure of the proportion of live, healthy cells within a population. Assays to assess cell viability measure metabolic activity, ATP content, cell proliferation, or membrane integrity.
A binary approach is one of the best ways to evaluate antibody specificity. By testing an antibody in biologically relevant positive and negative expression systems.
Cellular senescence is stable cell cycle arrest linked to aging and cancer and other disease states, including those associated with inflammation. It is induced by DNA damage, oncogenic signaling, and telomere shortening.
Discover the power of flow cytometry in cellular analysis and biomarker detection. Click here to learn more
Immunohistochemistry Basic Webinar (JP)