Basket Updated
0
Items added
Discover the autophagy pathway and its crucial role in cellular homeostasis. Learn more and uncover the mechanisms of cellular self-degradation here.
CST Technical Support Article
Learn about BCR signaling and how it can lead to changes in cell metabolism, gene expression, and cytoskeletal organization. Click here.
An antibody shouldn’t be one of the variables in your experiment. Find out why customers rank CST highest for antibody specificity and sensitivity.
Discover the PI3K Akt pathway and its crucial role in cell growth and survival. Click here to learn more & gain insights into this important signaling cascade
We currently have 6 total p53 antibodies reactive to human p53. All of these antibodies except #2524 and #30313 were produced by using the full-length human p53 as the immunogen. We currently have 1 additional total p53 antibody that binds to rodent p53, p53 (D2H9O) Rabbit mAb #32532. Please see below the comments about the epitopes of specific p53 antibodies.The p53 (1C12) Mouse mAb #2524 was produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser20 of human p53.Our mapping experiments for the p53 (7F5) Rabbit mAb #2527 have found that the epitope lies within the first 50 amino acids of the protein.Past mapping experiments of the p53 Antibody #9282 lots 3 and 4 have found several p53 regions that showed reactivity to this antibody. The most reactive residues lie within the first 100 amino acids of human p53, however, some reactivity was seen with sequences that lie within the DNA binding domain (aa102-292, UniProt ID P04637-1). Later, addi…
Designing or troubleshooting flow cytometry experiments to analyze intracellular signaling? Here’s what you need to know.
A scientific resource for the 14-3-3 protein domain containing information on structure, function, and binding to phospho-serine and phospho-threonine motifs.
U.S. Patent No. 6,441,140, directed to the production of a novel class of motif-specific, context-independent antibodies, highly useful for the identification of subclasses of protein kinase substrates.
A Hallmark of Cancer, sustaining proliferative signaling is used by cancer cells to stimulate growth and relies on Akt, MAPK/Erk, and MTOR pathways.
Highly specific and sensitive rabbit mAbs against B7 family targets, B7-H3 & B7-H4, are proven to outperform existing clones by WB.
Lymphoid lineage cells can be characterized using antibodies for cell type-specific markers, allowing cells to be visualized using flow cytometry or IHC.
Cancer cells adapt mechanisms to evade death by hijacking mechanisms of immune checkpoint control and modulation of the innate immune response via STING.
The ChIP Sonication Nuclear Lysis Buffer #28778 included in the SimpleChIP® Sonication Cell and Nuclear Lysis Buffers #81804 contains 0.1% SDS.
Feb 2008, CST continued collaboration with AstraZeneca to provide CST’s PhosphoScan® Platform for kinase inhibitor proteomic profiling.