Product Results

Cancer

Cancer is a complex and heterogeneous disease that arises from the disruption of normal cellular functions through genetic or epigenetic changes. To better understand the underlying mechanisms Hanahan and Weinberg created a list of 11 cancer hallmarks and two enabling traits which include: self-sufficiency in growth signals, insensitivity to anti-growth signals, evading apoptosis, limitless replicative potential, sustained angiogenesis, tissue invasion and metastasis, reprogramming energy metabolism and evading immune response, and the two enabling traits: genome instability and mutation, and tumor-promoting inflammation. Cell Signaling Technology (CST) has significant expertise backed by an extensive catalog of exceptionally reliable, sensitive, and validated products in support of diverse and dynamic cancer research needs from development of novel therapeutics to discovering new insights into cancer pathogenesis.

Hallmarks of Cancer

The 11 hallmarks of cancer as described by Hanahan and Weinberg provide an organizational structure for understanding cancer cell genotypes and assisting in development of novel therapeutics. CST offers the tools to interrogate these hallmarks through a comprehensive catalog of reliable and validated antibodies that target the following mechanisms: sustaining proliferative signaling, evading growth suppressors, avoiding immune destruction, enabling replicative immortality, tumor promoting inflammation, activating invasion and metastasis, inducing angiogenesis, genome instability and mutation, and resisting cell death.

Cancer Research Assays and Controls

Cell-based assays in cancer research are important tools for probing signaling pathways involved in tumorigenesis and metastasis. CST offers a variety of assays and kits that aid in the characterization of important cancer mechanisms and cellular pathways including: ALK and ROS1, caspase-3 activity, epigenetic biomarkers, and regulators and histone modifications for across a range of cancer types.

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#	Product Name	Application	Reactivity
36836	5-Carboxylcytosine (5-caC) (D7S8U) Rabbit mAb	WB IP IHC IF F ChIP	All	COMPARE COMPARE	Primary Antibodies
74178	5-Formylcytosine (5-fC) (D5D4K) Rabbit mAb	WB IP IHC IF F ChIP	All	COMPARE COMPARE	Primary Antibodies
51660	5-Hydroxymethylcytosine (5-hmC) (HMC31) Mouse mAb	WB IP IHC IF F ChIP	All	COMPARE COMPARE	Primary Antibodies
28692	5-Methylcytosine (5-mC) (D3S2Z) Rabbit mAb	WB IP IHC IF F ChIP	All	COMPARE COMPARE	Primary Antibodies
88439	53BP1 (E7N5D) XP^® Rabbit mAb	WB IP IHC IF F ChIP	H	COMPARE COMPARE	Primary Antibodies
6209	Phospho-53BP1 (Ser1618) (D4H11) Rabbit mAb	WB IP IHC IF F ChIP	H, R	COMPARE COMPARE	Primary Antibodies
2674	Phospho-53BP1 (Ser25/29) Antibody	WB IP IHC IF F ChIP	H, Mk	COMPARE COMPARE	Primary Antibodies
4908	53BP1 (P550) Antibody	WB IP IHC IF F ChIP	H, Mk	COMPARE COMPARE	Primary Antibodies
3428	Phospho-53BP1 (Thr543) Antibody	WB IP IHC IF F ChIP	H	COMPARE COMPARE	Primary Antibodies
2675	Phospho-53BP1 (Ser1778) Antibody	WB IP IHC IF F ChIP	H, Mk	COMPARE COMPARE	Primary Antibodies
4937	53BP1 Antibody	WB IP IHC IF F ChIP	H, Mk	COMPARE COMPARE	Primary Antibodies
24951	A1/Bfl-1 (E3U2F) Rabbit mAb	WB IP IHC IF F ChIP	H	COMPARE COMPARE	Primary Antibodies
17229	Pro-Survival Bcl-2 Family Antibody Sampler Kit II				Primary Antibodies
14093	A1/Bfl-1 (D1A1C) Rabbit mAb	WB IP IHC IF F ChIP	H	COMPARE COMPARE	Primary Antibodies
14138	Twinfilin-1 (D7C6J) Rabbit mAb	WB IP IHC IF F ChIP	H, M, R, Mk	COMPARE COMPARE	Primary Antibodies
8461	Twinfilin-1 Antibody	WB IP IHC IF F ChIP	H, M, R, Mk	COMPARE COMPARE	Primary Antibodies
12683	MDR1/ABCB1 (D3H1Q) Rabbit mAb	WB IP IHC IF F ChIP	H	COMPARE COMPARE	Primary Antibodies
13342	MDR1/ABCB1 (E1Y7B) Rabbit mAb	WB IP IHC IF F ChIP	H	COMPARE COMPARE	Primary Antibodies
13978	MDR1/ABCB1 (E1Y7S) Rabbit mAb	WB IP IHC IF F ChIP	H, M, R	COMPARE COMPARE	Primary Antibodies
14182	MRP3/ABCC3 (D1W1P) Rabbit mAb	WB IP IHC IF F ChIP	H	COMPARE COMPARE	Primary Antibodies
39909	MRP3/ABCC3 (D8V8J) Rabbit mAb	WB IP IHC IF F ChIP	H, M, R	COMPARE COMPARE	Primary Antibodies
12705	MRP4/ABCC4 (D2Q2O) Rabbit mAb	WB IP IHC IF F ChIP	H, M, Mk	COMPARE COMPARE	Primary Antibodies
12857	MRP4/ABCC4 (D1Z3W) Rabbit mAb	WB IP IHC IF F ChIP	H, M, R	COMPARE COMPARE	Primary Antibodies
97573	ABHD6 (D3C8N) Rabbit mAb	WB IP IHC IF F ChIP	H, M, R	COMPARE COMPARE	Primary Antibodies
9796	ACAD9 Antibody	WB IP IHC IF F ChIP	H, M, R, Mk	COMPARE COMPARE	Primary Antibodies
44276	ACAT1 Antibody	WB IP IHC IF F ChIP	H, M, R	COMPARE COMPARE	Primary Antibodies
13294	ACAT2 (E1L8V) Rabbit mAb	WB IP IHC IF F ChIP	H, Mk	COMPARE COMPARE	Primary Antibodies
14667	TPP1 (D4E2R) Rabbit mAb	WB IP IHC IF F ChIP	H, Mk	COMPARE COMPARE	Primary Antibodies
75352	Coronavirus Host Cell Attachment and Entry Antibody Sampler Kit				Primary Antibodies
45394	SARS-CoV-2 Virus-Host Interaction Antibody Sampler Kit				Primary Antibodies
3662	Acetyl-CoA Carboxylase Antibody	WB IP IHC IF F ChIP	H, M, R, Mk, B	COMPARE COMPARE	Primary Antibodies
8578	Acetyl-CoA Carboxylase 2 (D5B9) Rabbit mAb	WB IP IHC IF F ChIP	H	COMPARE COMPARE	Primary Antibodies
12589	Adipogenesis Marker Antibody Sampler Kit				Primary Antibodies
4190	Acetyl-CoA Carboxylase 1 Antibody	WB IP IHC IF F ChIP	H, M, R	COMPARE COMPARE	Primary Antibodies
3676	Acetyl-CoA Carboxylase (C83B10) Rabbit mAb	WB IP IHC IF F ChIP	H, M, R, Hm	COMPARE COMPARE	Primary Antibodies
3658	AceCS1 (D19C6) Rabbit mAb	WB IP IHC IF F ChIP	H, M, R, Mk	COMPARE COMPARE	Primary Antibodies
4934	Acinus Antibody	WB IP IHC IF F ChIP	H, M, R, Mk	COMPARE COMPARE	Primary Antibodies
6571	ACO2 (D6D9) XP^® Rabbit mAb	WB IP IHC IF F ChIP	H, M, R, Hm, Mk	COMPARE COMPARE	Primary Antibodies
47767	Tricarboxylic Acid Cycle Antibody Sampler Kit				Primary Antibodies
6922	ACO2 Antibody	WB IP IHC IF F ChIP	H, M, R, Mk	COMPARE COMPARE	Primary Antibodies
12861	Prostatic Acid Phosphatase (D3Y5P) Rabbit mAb	WB IP IHC IF F ChIP	H	COMPARE COMPARE	Primary Antibodies
19245	α-Smooth Muscle Actin (D4K9N) XP^® Rabbit mAb	WB IP IHC IF F ChIP	H, M, R	COMPARE COMPARE	Primary Antibodies
50513	α-Smooth Muscle Actin (D4K9N) XP^® Rabbit mAb (BSA and Azide Free)	WB IP IHC IF F ChIP	H, M, R	COMPARE COMPARE	Primary Antibodies
14968	α-Smooth Muscle Actin Antibody	WB IP IHC IF F ChIP	H, M, R	COMPARE COMPARE	Primary Antibodies
3700	β-Actin (8H10D10) Mouse mAb	WB IP IHC IF F ChIP	H, M, R, Hm, Mk, Dg	COMPARE COMPARE	Primary Antibodies
8456	Pan-Actin (D18C11) Rabbit mAb	WB IP IHC IF F ChIP	H, M, R, Mk	COMPARE COMPARE	Primary Antibodies
4970	β-Actin (13E5) Rabbit mAb	WB IP IHC IF F ChIP	H, M, R, Mk, B, Pg	COMPARE COMPARE	Primary Antibodies
48938	α-Smooth Muscle Actin (1A4) Mouse mAb (IF Formulated)	WB IP IHC IF F ChIP	H, M, R	COMPARE COMPARE	Primary Antibodies
4968	Pan-Actin Antibody	WB IP IHC IF F ChIP	H, M, R, Mk, Z	COMPARE COMPARE	Primary Antibodies
58169	β-Actin (E4D9Z) Mouse mAb	WB IP IHC IF F ChIP	H, M, R	COMPARE COMPARE	Primary Antibodies
56856	α-Smooth Muscle Actin (1A4) Mouse mAb (IHC Formulated)	WB IP IHC IF F ChIP	H, M, R	COMPARE COMPARE	Primary Antibodies
77397	TGF-β Fibrosis Pathway Antibody Sampler Kit				Primary Antibodies
8457	β-Actin (D6A8) Rabbit mAb	WB IP IHC IF F ChIP	H, M, R, Mk, Dm, Z	COMPARE COMPARE	Primary Antibodies
41185	Pan-Actin (C4) Mouse mAb	WB IP IHC IF F ChIP	H, M, R	COMPARE COMPARE	Primary Antibodies
31549	Cancer Associated Fibroblast Marker Antibody Sampler Kit				Primary Antibodies
4967	β-Actin Antibody	WB IP IHC IF F ChIP	H, M, R, Hm, Mk, Mi, Dm, Z, B	COMPARE COMPARE	Primary Antibodies
6487	α-Actinin (D6F6) XP^® Rabbit mAb	WB IP IHC IF F ChIP	H, M, R, Mk	COMPARE COMPARE	Primary Antibodies
3134	α-Actinin Antibody	WB IP IHC IF F ChIP	H, M, R, Hm, Mk	COMPARE COMPARE	Primary Antibodies
48243	Cardiogenesis Marker Antibody Sampler Kit				Primary Antibodies
13430	Focal Adhesion Protein Antibody Sampler Kit				Primary Antibodies
69758	α-Actinin (E7U1O) Mouse mAb	WB IP IHC IF F ChIP	H, M, R, Mk	COMPARE COMPARE	Primary Antibodies
15145	α-Actinin 4 (D7U5A) Rabbit mAb	WB IP IHC IF F ChIP	H, M, R	COMPARE COMPARE	Primary Antibodies
9189	ACSL1 (D2H5) Rabbit mAb	WB IP IHC IF F ChIP	H, M, R, Mk	COMPARE COMPARE	Primary Antibodies
4047	ACSL1 Antibody	WB IP IHC IF F ChIP	H, M, R	COMPARE COMPARE	Primary Antibodies
65184	Adenosine Deaminase (D1P4Y) Rabbit mAb	WB IP IHC IF F ChIP	H	COMPARE COMPARE	Primary Antibodies
14194	ADAM10 Antibody	WB IP IHC IF F ChIP	H	COMPARE COMPARE	Primary Antibodies
2099	ADAM9 Antibody	WB IP IHC IF F ChIP	H, M, R, Mk	COMPARE COMPARE	Primary Antibodies
4151	ADAM9 (D64B5) Rabbit mAb	WB IP IHC IF F ChIP	H, M, R, Mk	COMPARE COMPARE	Primary Antibodies
8658	Notch Receptor Interaction Antibody Sampler Kit				Primary Antibodies
84214	Phospho-α-Adducin (Ser12) (E5X8Y) Rabbit mAb	WB IP IHC IF F ChIP	H	COMPARE COMPARE	Primary Antibodies
70174	α-Adducin (D7T7R) Rabbit mAb	WB IP IHC IF F ChIP	H, Mk	COMPARE COMPARE	Primary Antibodies
45535	Perilipin-2 Antibody	WB IP IHC IF F ChIP	H	COMPARE COMPARE	Primary Antibodies
5295	ADH1 Antibody	WB IP IHC IF F ChIP	H, M	COMPARE COMPARE	Primary Antibodies
2789	Adiponectin (C45B10) Rabbit mAb	WB IP IHC IF F ChIP	H, M, R	COMPARE COMPARE	Primary Antibodies
14129	AEBP2 (D7C6X) Rabbit mAb	WB IP IHC IF F ChIP	H, M, R, Mk	COMPARE COMPARE	Primary Antibodies
62083	Polycomb Group 2 (PRC2) Antibody Sampler Kit				Primary Antibodies
5485	Phospho-Afadin (Ser1718) Antibody	WB IP IHC IF F ChIP	H	COMPARE COMPARE	Primary Antibodies
8683	Tight Junction Antibody Sampler Kit				Primary Antibodies
13531	Afadin (D1Y3Z) Rabbit mAb	WB IP IHC IF F ChIP	H, M, R, Mk, Dg	COMPARE COMPARE	Primary Antibodies
12684	AFAP1L2/XB130 (D1B5) Rabbit mAb	WB IP IHC IF F ChIP	H, Mk	COMPARE COMPARE	Primary Antibodies
12796	AFAP1L2/XB130 (D4A5) Rabbit mAb	WB IP IHC IF F ChIP	H, Mk	COMPARE COMPARE	Primary Antibodies
39971	AFP (C3) Mouse mAb	WB IP IHC IF F ChIP	H	COMPARE COMPARE	Primary Antibodies
4448	AFP (D12C1) Rabbit mAb	WB IP IHC IF F ChIP	H	COMPARE COMPARE	Primary Antibodies
58662	AGK Antibody	WB IP IHC IF F ChIP	H	COMPARE COMPARE	Primary Antibodies
14937	AGPAT2 (D8W9B) Rabbit mAb	WB IP IHC IF F ChIP	H	COMPARE COMPARE	Primary Antibodies
13062	AGR2 (D9V2F) XP^® Rabbit mAb	WB IP IHC IF F ChIP	H	COMPARE COMPARE	Primary Antibodies
94248	AHCYL1/IRBIT (D3A5G) Rabbit mAb	WB IP IHC IF F ChIP	H, M, R, Mk	COMPARE COMPARE	Primary Antibodies
17336	One-Carbon Metabolism Antibody Sampler Kit				Primary Antibodies
83200	AhR (D5S6H) Rabbit mAb	WB IP IHC IF F ChIP	H	COMPARE COMPARE	Primary Antibodies
5318	AIF (D39D2) XP^® Rabbit mAb	WB IP IHC IF F ChIP	H, M, R, Mk	COMPARE COMPARE	Primary Antibodies
11843	Cell Fractionation Antibody Sampler Kit				Primary Antibodies
8653	Organelle Localization IF Antibody Sampler Kit				Primary Antibodies
4642	AIF Antibody	WB IP IHC IF F ChIP	H, M, R	COMPARE COMPARE	Primary Antibodies
30182	Mouse Reactive Alzheimer's Disease Model Microglia Phenotyping IF Antibody Sampler Kit				Primary Antibodies
97624	Mouse Reactive M1 vs M2 Macrophage IHC Antibody Sampler Kit				Primary Antibodies
90298	Mouse Microglia Marker IF Antibody Sampler Kit				Primary Antibodies
24972	AIFM2/FSP1 Antibody	WB IP IHC IF F ChIP	H	COMPARE COMPARE	Primary Antibodies
25620	Human Reactive Inflammasome Antibody Sampler Kit II				Primary Antibodies
20836	Mouse Reactive Inflammasome Antibody Sampler Kit				Primary Antibodies
56612	Hippo Pathway: Upstream Signaling Antibody Sampler Kit				Primary Antibodies

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Cancer

Hallmarks of Cancer

Cancer Research Assays and Controls

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