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Cleaved caspase-3 product listings, product citations, comparison tables and educational resources for apoptosis signaling from Cell Signaling Technology.
Caspase Cleavage Substrate Proteomics
Find out the best control cell extracts to use as positive or negative controls in your western blots, when studying apoptosis, autophagy, and mitophagy.
Study the intricate machinery of the apoptosis signaling pathway. Click here to learn more and gain insights into programmed cell death mechanisms.
Apoptosis is a type of programmed cell death that occurs normally throughout the lifespan and can also occur in response to harmful stimuli. Apoptotic cells are identified by their altered morphology, caspase activation, and the presence of damaged DNA.
Expert-reviewed interactive pathway providing a current overview of Death Receptor Signaling.
Products and Related Resources for Cell Death and Viability SARS-CoV-2 Research
Necrosis has been classically defined as an unprogrammed form of cell death that occurs in response to overwhelming chemical or physical insult.
Overview of apoptosis signaling networks, antibodies and related reagents, interactive pathway diagrams, and technical resources for apoptosis research.
Compare Cell Signaling Technology's Cleaved Caspase antibodies against one another to determine optimal applications.
Regulation of cell death due to viral infection is important for host survival. In this series, we look at pathways regulated through cellular responses to viruses.
A scientific resource for the BIR protein domain containing information on structure, function, and domain binding in apoptosis.
Caspase-3 Activity Protocol: easy to follow directions describing the step by step experimental procedure.
A scientific resource for the DED protein domain containing information on structure, function, and domain binding during apoptosis.
The Inflammasome pathway is essential for the innate immune response, but it can also contribute to the onset of a number of diseases. Learn more here.
Apoptosis is a regulated form of programmed cell death (PCD) that occurs without external influence.
Pyroptosis is a type of programmed necrotic cell death activated by infections from bacteria, viruses, fungi or protozoa in the presence of PAMPs or DAMPs
Cell viability is a measure of the proportion of live, healthy cells within a population. Assays to assess cell viability measure metabolic activity, ATP content, cell proliferation, or membrane integrity.
These markers can be used to study necroptosis and pyroptosis, forms of regulated necrotic cell death that share morphological features with necrosis.
Products and Related Resources for Virus Detection and Innate Immune Activation SARS-CoV-2 Research
细胞焦亡与其他多种细胞程序性死亡形式之间存在相互联系和转化,共同构成细胞程序性死亡的复杂体系,维持细胞和机体的内稳态。
Activated by pro-inflammatory signaling, ischemic injury or viral infection, necroptosis is a programmed regulated form of necrosis requiring RIP3 and MLKL
Expert-reviewed interactive pathway providing a current overview of Inhibition of Apoptosis Signaling.
Cancer cells resist inhibitory signals that might otherwise stop their growth. The major pathways involved are Autophagy and Apoptosis.
Explore the mitochondrial apoptosis pathway and its role in programmed cell death. Read more about this essential pathway here.
Cancer cells can resist death. They evade apoptosis, the mechanism that programs cell death once cells become damaged. Normally, apoptosis helps keep an organism healthy through growth and development, but cancer cells do not follow this process, no matter how abnormally they grow.
Cell states can be monitored using markers correlating to your process of interest. These assays and antibodies can be used to detect cell viability, senescence, proliferation, apoptosis, cytotoxicity and oxidative state.
Alphabetical listing of protein, pathway, and antibody acronyms, curated by Cell Signaling Technology.