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Learn about BCR signaling and how it can lead to changes in cell metabolism, gene expression, and cytoskeletal organization. Click here.
Ensure equal sample loading with loading control antibodies from CST.
Explore the NFkB pathway and its impact on inflammation and immune responses. Click here to learn more about this signaling pathway.
Discover the PI3K Akt pathway and its crucial role in cell growth and survival. Click here to learn more & gain insights into this important signaling cascade
Discover the autophagy pathway and its crucial role in cellular homeostasis. Learn more and uncover the mechanisms of cellular self-degradation here.
Western Blotting troubleshooting guide for easy to solve high and low background issues.
Expert-reviewed interactive dopamine signaling pathway providing a current overview of Dopamine in Parkinson's Disease. Learn more here.
We have not conducted any fluorescent western blot multiplex experiments with p53. Unfortunately, many p53 antibodies have antigenic regions that overlap or have not been precisely mapped. For human samples, our Phospho-p53 (Ser15) Antibody #9284 or our Phospho-p53 (Ser15) (E9Y4U) Rabbit mAb #82530 in combination with p53 (DO-7) Mouse mAb #48818 may work, however, the binding epitope of #48818 has not been mapped. Alternatively, our Phospho-p53 (Ser15) (16G8) Mouse mAb #9286 could be tried in combination with our p53 (E9B5W) Rabbit mAb #30313. #30313 is the only total p53 antibody that we know has an epitope that resides outside of the N-terminus in the p53 tetramerization domain.
Our validation of the Annexin V-FITC Early Apoptosis Detection Kit #6592 was performed using live cells in suspension, but the steps can be carried out on live adherent cells as well. If the option is available to scrape the cells from the growth surface and perform the staining in suspension, this would be the easiest way to follow the directions for use on the datasheet. Otherwise we suggest following the directions as closely as possible for adherent cells.
Highly specific and sensitive rabbit mAbs against B7 family targets, B7-H3 & B7-H4, are proven to outperform existing clones by WB.
Protein enrichment by immunoprecipitation is frequently carried out prior to analysis. In this Tech Tip, Sarah presents considerations for choosing antibodies and beads for IP.
Designing or troubleshooting flow cytometry experiments to analyze intracellular signaling? Here’s what you need to know.
CST is proud to partner with global green chemistry nonprofit Beyond Benign to support the creation of green chemistry teaching resources for STEM education.
Cell Signaling Technology announces the launch of SignalStar™ Multiplex IHC, a flexible spatial biology solution for up to 8-plex amplification in two days.
Cell Signaling Technology (CST), a leading provider of antibodies, kits, and services, was honored with the 2017 CiteAb Award for &quoPTM Antibody Company of the Year" and for a third year in a row with the award for "Researchers’ Choice."
CiteAb Names Cell Signaling Technology "Antibody Company of the Year" and "Antibody Company Succeeding in Cancer Biology"
Oct 2007, CST announced the availability of PhosphoScan® profiling technology and PhosphoSite® knowledge base to academic researchers.
CiteAb Names Cell Signaling Technology, "Antibody Company of the Year" and "Researchers’ Choice"
Tissue clearing has paved the way for intact brain imaging with molecular phenotyping. The technology is rapidly evolving and shows great potential.
Cancer cells adapt mechanisms to evade death by hijacking mechanisms of immune checkpoint control and modulation of the innate immune response via STING.
Cell Signaling Technology (CST) Drives Sustainability in the Life Sciences Through My Green Lab Sponsorship
Cell Signaling Technology (CST) Enters Agreement with Roche for CDx Development
Feb 2008, CST announced continued PhosphoScan® proteomics research project with Bristol-Myers Squibb for kinase inhibitor profiling.