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Neuroinflammation is a condition observed in the central nervous system (CNS) in response to infection, toxic metabolites, traumatic injury, or autoimmunity.
Cellular senescence is characterized by irreversible cell-cycle arrest in combination with a distinct secretory phenotype and expanded lysosomes in response to stress. Senescent cells accumulate in tissues during aging, and various markers of senescence
Epigenetic regulation, including aberrant DNA methylation and histone modifications, have been linked to Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis.
The complexity of the proteome makes discovery research seem like trying to find a needle in a haystack. Learn how enrichment with PTMScan decreases sample complexity and increases the likelihood that you'll find what you're looking for.
Learn how PTMScan technology facilitates translational discovery, identification of disease drivers, and development of markers and treatments, as exemplified in the study of non-small cell lung cancer (NSCLC).
Targeted protein degradation selectively alters protein abundance by co-opting the cellular degradation machinery. The degradation tag (dTAG) system can be used for target validation and mechanistic studies.
Use our protocol compatibility table to understand which immune signaling and phenotyping antibodies will work together in your multicolor flow cytometry experiment.
Multiplex immunohistochemistry (mIHC): Perform in depth tissue analysis on a single slide to understand protein co-localization and spatial context
Learn to ChiP
Chromatin Immunoprecipitation Troubleshooting Guide: easy to follow directions describing the step by step experimental procedure.
Find out which epigenetic markers are important drivers in mixd lineage leukemia, or MLL.
ChIP Basic Webinar (JP)
Discover the most important epigenetic markers that contribute to the progression of diffuse intrinsic pontine glioma (DIPG).
Discover the key RNA binding proteins (RBPs) in the lifecycle of messenger RNA (mRNA)
Immunohistochemistry is a method for studying antigen localization in tissue sections using antibodies. Learn sample preparation, labeling, & visualization.
How does ELISA work? Understand ELISA principles for accurate molecule detection and quantification through antibody-based assays. Click here
本视频提供适用于石蜡包埋的组织切片的免疫组织化学实验步骤分步指南,Cell Signaling Technology IHC 团队的科学家使用的正是这样的指南