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Epigenetics

Epigenetics

Epigenetics is defined as the study of heritable phenotypic changes in organisms that do not involve alterations to the DNA sequence. In other words, epigenetics involves the study of DNA modifications, histone modification, and chromatin-regulatory proteins that regulate heritable changes in gene expression. Understanding epigenetic drivers of disease is critical in the detection and prevention of transcriptional abnormalities found in cancer as well as some metabolic, neurological, inflammatory, and cardiovascular disorders. The ability to interrogate epigenetic changes in cells and tissues could provide insights into causative mechanisms of disease and normal function and development. Towards this goal, Cell Signaling Technology (CST) provides a comprehensive platform including a diverse catalog of products, epigenetics assays, and resources such as the PhosphoSitePlus® database.

DNA Methylation

DNA methylation is a critical epigenetic modification that is linked to many important cellular processes related to chromosome inactivation, aging, and cancer - nearly every type of cancer shows deregulation of DNA methylation, manifesting as global hypomethylation and localized hypermethylation at some gene enhancers and promoters. CST can assist your discovery research efforts with a wide variety of validated antibodies, for a diverse set of applications, related to DNA methylation from our extensive catalog of products.

Histones and Histone Modifications

Post-translational modification (PTM) of histones (e.g., acetylation, phosphorylation, methylation, ubiquitination) impacts gene expression, genome organization, cell division, and the DNA damage response. Our modification-specific histone antibodies including ChIP and CUT&RUN validated antibodies, can enable your understanding of the function and interactions of the ever-increasing repertoire of known histone PTMs.

Histone Modifications: Writers, Readers, and Erasers

Writers, readers, and erasers interact with histones to modify and recognize epigenetic marks on chromatin. Understanding the relationships among these three classes of proteins is important to unravel the mechanisms regulating gene expression and genome organization in normal and diseased cell states. CST offers a diverse selection of products that can capture the dynamic process of writing, reading, and erasing modifications including ubiquitination, acetylation, phosphorylation and methylation.

ATP-Dependent Chromatin Remodeling

The modulation of chromatin structure by ATP-dependent chromatin remodelers affects gene expression, genomic repair mechanisms, cell growth, differentiation, and the cell cycle—all key factors, that when disrupted, could lead to disease. A crucial component of gene expression and differentiation is the ATP-dependent chromatin remodeling complex BRG1-associated factor complex (BAF) of which mutations are frequently associated with cancer. CST offers a diverse selection of products including ChIP and CUT&RUN validated antibodies and antibodies for immunohistochemistry (IHC), related to the BAF complex and other ATP-dependent chromatin remodeling complexes to better understand disease mechanisms.

Nuclear Receptors

Nuclear receptors not only function as traditional ligand receptors, but also directly bind to DNA and regulate gene expression, with significant roles in the pathology of cancer and autoimmune disorders. CST has a wide variety of reliable and validated ChIP and immunohistochemistry (IHC)-related products to investigate the relationships between nuclear receptors and target genes.

Transcriptional Machinery

Many cancers, autoimmune disorders, and metabolic and cardiovascular diseases, are characterized by the dysregulation of transcription, which can be caused by mutated or altered components in the transcriptional machinery. We provide tools for discovering new insights into the regulatory signals between gene activation and the transcriptional machinery.

Nuclear Structure

The pathological staging of tumors and epigenetic changes can be observed in the altered morphology of the cell nucleus. Therefore, the reliability and accuracy of antibodies to visualize these structural changes and reorganization is incredibly important. CST offers a diverse selection of validated antibodies to provide you with confident results when assessing the nuclear structure to better understand cancer progression.

Chromosome Cohesion and Condensation

Genomic stability and DNA repair are promoted through chromosome cohesion and condensation, and the disruption of these processes can lead to diseases such as cancer. In order to develop improved treatments, we must understand the mechanisms of aberrant genomic stability. Let CST assist you with our catalog of validated products as you explore the fine balance between genomic stability and diversity.

Antibody Sampler Kits

Our expert scientists have thoughtfully curated our sampler kits to help you obtain reliable data in your epigenetics research. CST sampler kits provide an economical option for evaluating a variety of different epigenetic marks and regulators such as methylated Histone H3, phosphorylated RNA PolII, the BAF complex, and regulators of DNA methylation.

Assays & Kits

In order to understand the complex epigenetic mechanisms regulating gene expression and genomic structure, CST offers SimpleChIP® and CUT&RUN assay kits as well as workflow reagents for the detection of protein-DNA interactions across the genome and ELISA kits for measuring expression of epigenetic modifications and regulators in normal and diseased states. As you investigate drug mechanisms to treat epigenetic diseases, partner with us to find the best assay/kit for your experimental needs.

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