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When performing western blot using our COL1A1 antibodies, we detect the propeptide form of COL1A1, which is observed around 220kDa. The propeptide COL1A1 is processed to a mature form by cleavage of the N-terminal 1-161AA chain and the C-terminal 1219-1464AA portion resulting in a ~140kDa protein (UniProt ID P02452). This mature form may be detected by our COL1A1 antibodies when analyzing tissue samples but is not commonly observed in our hands in cell lysates.