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Expert-reviewed interactive pathway providing a current overview of Hippo Signaling.
Expert-reviewed interactive pathway providing a current overview of PTM Crosstalk Signaling.
Explore the mitochondrial apoptosis pathway and its role in programmed cell death. Read more about this essential pathway here.
Expert-reviewed interactive pathway providing a current overview of Cell Cycle G2/M DNA Damage Signaling.
Study the intricate cell cycle pathway's regulation of cell division and proliferation. Learn more here.
Study the intricate machinery of the apoptosis signaling pathway. Click here to learn more and gain insights into programmed cell death mechanisms.
A scientific resource for the 14-3-3 protein domain containing information on structure, function, and binding to phospho-serine and phospho-threonine motifs.
Expert-reviewed interactive pathway providing a current overview of T Cell Receptor (TCR) Signaling.
The PI3K / Akt Substrates Table provides a comprehensive list of demonstrated downstream targets of Akt phosphorylation.
For antigenic targets where expression of the protein is very low or unknown, the use of recombinant proteins or exogenous expression in a surrogate cell line may be necessary for antibody validation.
A categorical list of protein domain resources by Cell Signaling Technology. Each resource contains specific domain structure, function, and binding information.
Validation using recombinant proteins or exogenous expression in a surrogate cell line can be used for targets with low levels of protein expression.
KinomeView® Profiling Kit and Services
PhosphoScan® Phosphorylation Proteomics
Expert-reviewed interactive pathway providing a current overview of Cell Cycle G1/S Checkpoint Signaling.
The official blog of Cell Signaling Technology, where we discuss what to expect from your time at the bench and share tips, tricks, and information.
Expert-reviewed interactive pathway providing a current overview of Contribution of Extracellular Matrix to EMT Signaling.
Expert-reviewed signaling pathway providing a current overview of adherens junction dynamics and links to products by Cell Signaling Technology.
Interact with this diagram showing the epigenetic regulators of Histone H3 including those responsible for monomethylation, asymmetric and symmetric dimethylation, and trimethylation.
Immunohistochemistry (IHC) is a powerful technique. Learn how to perform IHC on paraffin sections with our step-by-step IHC protocol. Click here.
Interact with this diagram showing the epigenetic writers and erasers of histone H2A, histone H2B, and Histone H4, including the involvement of acetyltransferases, deacetylases, methyltransferases, demethylases and kinases.
The Histone Modification Table provides a referenced list of many known histone modifications, associated modifying enzymes, and proposed functions.
Immunohistochemistry Protocol (Paraffin) - Specific for Product: easy to follow directions describing the step by step experimental procedure.
Immunohistochemistry Protocol (Paraffin): easy to follow directions describing the step by step experimental procedure.
Discover the PI3K Akt pathway and its crucial role in cell growth and survival. Click here to learn more & gain insights into this important signaling cascade
While healthcare providers and researchers race treat COVID-19, the quality of the tests themselves threatens to undermine their progress.
Our CGRP (D5R8F) Rabbit mAb #14959 is produced with a synthetic peptide corresponding to residues surrounding Val114 of human CGRP protein (UniProt ID P06881 isoform 3; http://www.uniprot.org/uniprot/P06881). Isoform 3 has a predicted molecular weight (MW) of 14 kDa, but is further processed into the mature α-CGRP protein (calcitonin gene-related peptide 1). #14959 is also likely to detect β-CGRP protein (calcitonin gene-related peptide 2), which is encoded by a second distinct gene [i.e., CALCB (UniProt ID P10092; http://www.uniprot.org/uniprot/P10092)]. α-CGRP and β-CGRP are the mature peptides of 37 amino acids with predicted MWs of 3.8 kDa. The western blot images on the product datasheet show detection of α-CGRP and/or β-CGRP proteins (apparent molecular weights on Tris-Glycine gels of approximately 5-10 kDa) However, the antibodies are also predicted to detect the unprocessed precursors.
It was too difficult for scientists to uncover the peptides for which they enriched, so scientists from the Broad Institute and CST® created a new method.
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
A scientific resource for the BRCT protein domain containing information on structure, function, and binding to phospho-serine motifs.
