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Find out which epigenetic markers are important drivers in mixd lineage leukemia, or MLL.
Epigenetic regulation, including aberrant DNA methylation and histone modifications, have been linked to Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis.
Protein-DNA interactions mediate epigenetic processes. Researchers studying these interactions need a means of analyzing when & where they occur on the genome.
The Histone Modification Table provides a referenced list of many known histone modifications, associated modifying enzymes, and proposed functions.
Alphabetical listing of protein, pathway, and antibody acronyms, curated by Cell Signaling Technology.
Learn here about the HIF-1 signaling pathway and its impact on oxygen homeostasis and cellular adaptation. Click here.
Expert-reviewed interactive pathway providing a current overview of Protein Acetylation.
Expert-reviewed interactive pathway providing a current overview of Cell Cycle G2/M DNA Damage Signaling.
Information and case study data for the PTMScan Direct Cell Cycle and DNA Damage Service offered by CST.
Expert-reviewed interactive pathway providing a current overview of the Inflammasome Signaling Pathway.
Several different assays can be used by scientists to measure metabolism in a variety of contexts. These include methods to determine metabolic rates, key signaling pathways, and environmental cues.
Streamline your oncology therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
The activity of genes and their regulatory elements is, in part, governed by their cell type-specific chromatin organization.
A scientific resource for the FYVE protein domain containing information on structure, function, and binding to phospholipids.
A video tutorial illustrating the methodology behind PTMScan Technology and an example of its use in a recent phosphoproteomic study authored by scientists from CST.
Explore the NFkB pathway and its impact on inflammation and immune responses. Click here to learn more about this signaling pathway.
This video introduces PTMScan technology, a platform for the enrichment of post-translational modifications (PTMs) in mass spectrometry-based proteomics studies.
Synopsis of CST scientists' publication in the journal Science Signaling describing phosphorylation patterns associated with non-small cell lung cancer (NSCLC).
Study the intricate cell cycle pathway's regulation of cell division and proliferation. Learn more here.
Study the ubiquitin proteasome pathway and its critical role in protein degradation and cellular homeostasis. Expert reviewed pathways.
Streamline your neurodegeneration therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
Expert-reviewed interactive pathway providing a current overview of angiogenesis pathways and links to products by Cell Signaling Technology.
Immunohistochemistry Protocol (Paraffin): easy to follow directions describing the step by step experimental procedure.
Immunohistochemistry Protocol (Paraffin) - Specific For Products: 2085, 3197: easy to follow directions describing the step by step experimental procedure.
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
Information and case study data for the PTMScan Direct Ser/Thr Kinases Service, which allows for the targeted screening of a defined set of protein modification sites.
