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Click here to discover the intricacies of methylation pathways and their role in gene regulation and epigenetic modifications.
The activity of genes and their regulatory elements is, in part, governed by their cell type-specific chromatin organization.
Information and case study data for the PTMScan Direct Ser/Thr Kinases Service, which allows for the targeted screening of a defined set of protein modification sites.
This is a four-part series featuring tips to improve your ChIP protocol.
Use SimpleChIP kits to perform high throughput ChIP-Sequencing and assay genome wide changes in histone modifications and transcription factor binding.
Learn more about how intracellular flow cytometry can be used to measure unique signaling events to do with apoptosis, pluripotency status and epigenetic activity.
Use our protocol compatibility table to understand which immune signaling and phenotyping antibodies will work together in your multicolor flow cytometry experiment.
Find out which epigenetic markers are important drivers in mixd lineage leukemia, or MLL.
Assay Kits from CST contain ChIP validated antibodies and control PCR primers to assay for pluripotency markers or epigenetic mark status in human or mouse samples.
Interact with this diagram showing the epigenetic writers and erasers of histone H2A, histone H2B, and Histone H4, including the involvement of acetyltransferases, deacetylases, methyltransferases, demethylases and kinases.
Proteomics can help elucidate mitochondrial homeostasis and dysfunction, inflammasome activation, and the role of parkin in Parkinson's disease.
Expert-reviewed interactive pathway providing a current overview of PTM Crosstalk Signaling.
Expert-reviewed interactive pathway providing a current overview of Histone Methylation.
Expert-reviewed interactive pathway providing a current overview of Protein Acetylation.
An orthogonal antibody validation strategy is critical to verify existing validation data and identify any effects or artifacts that are directly related.
Interact with this diagram showing the epigenetic regulators of Histone H3 including those responsible for monomethylation, asymmetric and symmetric dimethylation, and trimethylation.
Scientific posters presented by CST scientists at various conferences and trade shows through the years.
An orthogonal strategy for antibody validation involves cross-referencing antibody-based results with data obtained using non-antibody-based methods.
Mass spectrometry-based proteomic methods like PTMScan can be applied in translational research. For example to identify novel biomarkers of disease
Bay State Bike Week and the Mass Commute Bicycle Challenge is a great event to promote cycling and build community spirit. CST is looking forward to Bike Week next year where we hope to break the 2,100 mile mark!
Trademark information appearing on Cell Signaling Technology website.
Expert-reviewed interactive pathway providing a current overview of the Warburg Effect.
The official blog of Cell Signaling Technology, where we discuss what to expect from your time at the bench and share tips, tricks, and information.
There is still much to learn about the hidden layer of gene regulation—the chemical modification of RNA. What is the effect of m6A, the most abundant mRNA modification observed in eukaryotes?
Cell Signaling Technology (CST) talks March for Science and what we can do to stay green this upcoming Earth Day.
How can I determine the different ways a protein can affect gene expression? ChIP, CUT&RUN, & Nex-gen Sequencing. Learn how to research gene expression.
Tissue clearing has paved the way for intact brain imaging with molecular phenotyping. The technology is rapidly evolving and shows great potential.
The Histone Modification Table provides a referenced list of many known histone modifications, associated modifying enzymes, and proposed functions.
New antibodies for Alzheimer's research were presented at SfN 2022, including tools to study neuroinflammation in glial cells like microglia and astrocytes
The Kinase Library can determine the kinases likely to phosphorylate any given motif. Learn about the research enabling this phosphoproteomics revolution.
