Understanding the organization and function of the brain and nervous system is vital to explain the etiology of devastating neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). Elucidate the mechanisms that drive neurodegenerative disease - including the molecular and cellular events related to the structure and function of cell types found in the brain including neurons, microglia, oligodendrocytes, and astrocytes - with validated antibodies from Cell Signaling Technology (CST) for your research.
The Hallmarks of Neurodegeneration include Protein Folding and Aggregation, Neuroinflammation, Acquiring Senescence (as well as altered cell signaling), Epigenetics, and Metabolism. Cell Signaling Technology (CST) offers a variety of validated antibodies for markers of neurodegeneration to generate high quality neuropathological data in order to understand disease progression.
Genetics is the major driver of functional studies revealing candidate biomarkers or therapeutic targets for neurodegenerative diseases. The aggregation of proteins in the brain is a common feature of many neurodegenerative diseases and is assumed to play a significant role in neuropathogenesis. Our expert scientists and diverse catalog of antibodies enables you to identify proteins involved in aggregation including amyloid beta plaques and tau tangles.
The central and peripheral nervous systems consist of an assortment of cell types with varying functions in development, adult neurogenesis, and pathogenesis of neurodegenerative diseases. CST has developed and validated antibodies in more than one host species - permitting multiplexing for high-throughput potential - to identify numerous types of neuronal and glial cells and facilitate the complex cellular characterization of the brain.
The right antibodies can provide detailed information on vesicle trafficking, synaptic transmission, and cell behavior involved in neural function. CST offers a diverse selection of validated antibodies for obtaining spatial data, synaptic transmission, and plasticity using techniques that include both immunohistochemistry (IHC) and immunofluorescence (IF).
Evaluation of neurological pathways is complex and generally involves different methods of phenotypic assessment. CST offers a variety of antibody sampler kits to support your neurological research with relevant disease readouts by western blot and other assays.
CST offers a diverse variety of assays and kits to assist your discovery of targets in neural development, neural function, synaptic signaling, biomarkers, neurodegeneration, and other neural pathologies. Choose from our reliable assays and kits to simplify your experiments and give you more time to analyze data on the different mechanisms involved in nervous system regulation.
Neurological function and development can be visualized using high quality conjugates that provide insights into the mechanisms of normal neural function and several neurological diseases. Choose from our diverse catalog of conjugates, including fluorophores for imaging and biotin for assay development, in order to obtain the phenotypic information best suited for your neurological research.