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Overview of MAP Kinase signaling pathways, antibodies and related reagents, interactive pathway diagrams, and other technical resources.
Compare Cell Signaling Technology's Erk antibodies against one another to determine optimal applications
Phospho-Erk product lists, product citation lists, product selection tools, comparison tables and educational resources for MAPK signaling from Cell Signaling Technology.
Interactive p38 MAPK pathway. Learn how p38 MAPK is involved in regulation of HSP27, MAPKAPK-2, MAPKAPK-3, & several transcription factors.
Explore the ERK pathway and its role in cell proliferation and survival. Click here to read more about this critical signaling pathway.
Exactly what is ELISA? Learn about the enzyme-linked immunosorbent assay, the specific interaction between antibody & antigen. Click here.
Overview of PI3K/Akt signaling pathways, antibodies and related reagents, interactive pathway diagrams, and other technical resources.
Explore the G protein coupled receptor signaling pathway and its diverse roles in cellular communication. Read more here.
Cell Signaling Technology pathways by research area
Expert-reviewed interactive pathway providing a current overview of ErbB/HER Signaling.
Melanomas account for 90% of skin cancer deaths. A big contributor to this: the lack of effective, durable treatments for unresectable, metastatic melanoma.
Identifies and quantifies up to many hundreds of critical signaling nodes across pathways involved in cancer biology, immune cell signaling, and more.
Catalog numbers in tabular format for control cell extracts and proteins with links to product pages.
Learn more about commonly used chemical modulators to study cellular physiology and biology.
A Hallmark of Cancer, sustaining proliferative signaling is used by cancer cells to stimulate growth and relies on Akt, MAPK/Erk, and MTOR pathways.
Products and Related Resources for Cytokines and Inflammation SARS-CoV-2 Research
Case Study 3: Exceptional Reproducibility of XP Monoclonal Antibodies from Cell Signaling Technology.
Products and Related Resources for Fibrosis SARS-CoV-2 Research
Illustration of Motif Antibody Coverage
Understand when to use immunohistochemistry (IHC) over any other technique including Immunocytochemistry, Western Blot and ELISA
The accuracy of western blot results relies heavily on the quality of the primary antibody used. CST™ antibodies are validated using multiple experiments.
Western blotting using fluorescent-conjugated secondary antibodies - accurate quantification and two-color multiplexing using primary antibodies from different species.
Case Study 1: Exceptional Specificity of XP Monoclonal Antibodies pertaining to eXceptional Monoclonal Technology (XMT) from Cell Signaling Technology.
Overview of GPCR, Calcium, cAMP Signaling Resources, interactive pathway diagrams, and other technical resources.
Expert-reviewed interactive pathway providing a current overview of SAPK/JNK Signaling.
The transcriptional activity of c-Jun is regulated by SAPK/JNK phosphorylation at Ser63 and Ser73. The signaling pathway can be found at https://www.cellsignal.com/contents/science-pathway-research-mapk-signaling/sapk-jnk-signaling-pathway/pathways-mapk-sapk. Cellular stressors, such as UV radiation, inflammatory cytokines, or ceramide, activate Rho-family GTPases and subsequent MAPKKK (Map Kinase Kinase Kinase) pathways. MAPKKKs can activate MKK4/7, which directly phosphorylate and activate SAPK/JNK. Upon translocation to the nucleus, SAPK/JNK can activate c-Jun and other transcription factors. Proteins generally undergo a phosphorylation dependent mobility shift (PDMS) in SDS-PAGE. This shift can vary from target to target, and even with different activation events on the same target. Recent experiments suggest this is due to the additional negative charge conferred by phosphorylation sites disrupting protein binding to SDS (see https://www.researchgate.net/publication/264031559_Phosphorylation-Depe…
Discover the TGF Beta signaling pathway and impact on cell growth & tissue homeostasis. Learn here the mechanisms behind this vital signaling cascade.
Discover the insulin signaling pathway and its role in glucose metabolism & diabetes. Learn more about insulin action here.
