Basket Updated
0
Items added
mTOR is the catalytic subunit of two functionally distinct complexes, mTOR Complex 1 (mTORC1) and mTOR Complex 2 (mTORC2). mTORC1 is composed of mTOR, Raptor, mLST8/GL, PRAS40 and DEPTOR. mTORC2, on the other hand, is composed of mTOR, Rictor, GßL, and mSIN1. Our total mTOR antibodies (#2983, #2972, and #4517) recognize total mTOR kinase in both complexes.
Discover the mTOR pathway and its role in cellular growth and metabolism. Click here to explore the intricacies of this vital signaling pathway.
Information and case study data for the PTMScan Direct PI3K/Akt Service offered by CST, which allows for targeted screening of 105 proteins within the Akt pathway.
Several different assays can be used by scientists to measure metabolism in a variety of contexts. These include methods to determine metabolic rates, key signaling pathways, and environmental cues.
Zika virus turns off Akt signaling to hijack autophagy in developing neural tissue
Resources for the study of Translational Control, Protein Synthesis, and RNA Regulation including antibodies and associated reagents and interactive pathway diagrams.
The three main purposes of metabolism are the conversion of food to energy; the conversion of nutrients to proteins, carbohydrates, lipids, and nucleic acids; and the elimination of nitrogenous wastes. There is a strong correlation between metabolic chan
Information and case study data for the PTMScan Direct Apoptosis/Autophagy Service offered by CST.
Overview of PI3K/Akt signaling pathways, antibodies and related reagents, interactive pathway diagrams, and other technical resources.
A Hallmark of Cancer, sustaining proliferative signaling is used by cancer cells to stimulate growth and relies on Akt, MAPK/Erk, and MTOR pathways.
Tumor cells adopt novel mechanisms to acquire nutrients and reprogram metabolic pathways to meet their increased bioenergetics demands. CST provides tools to detect and measure key metabolic changes.
Information and case study data for the PTMScan Direct Ser/Thr Kinases Service, which allows for the targeted screening of a defined set of protein modification sites.
Overview of autophagy signaling, antibodies and related reagents, interactive pathway diagrams, and technical resources for autophagy research.
Discover the autophagy pathway and its crucial role in cellular homeostasis. Learn more and uncover the mechanisms of cellular self-degradation here.
Autophagy helps normal cells maintain homeostasis and acts as a survival mechanism in response to stress, where ULK1 plays an important role in signaling.
Find Pathways and Diagrams By Disease Area
Expert-reviewed interactive pathway providing a current overview of Regulation of eIF4E and p70 S6K.
"PI3K/Akt signaling is close to my heart because certain diseases that have cropped up in my family are linked to specific proteins in this pathway."
This video introduces PTMScan technology, a platform for the enrichment of post-translational modifications (PTMs) in mass spectrometry-based proteomics studies.
Resources include signaling pathways, antibodies and companion products, research overviews, technical resources, and recent review articles.
Synopsis of CST scientists' publication in the journal Science Signaling describing phosphorylation patterns associated with non-small cell lung cancer (NSCLC).
A video tutorial illustrating the methodology behind PTMScan Technology and an example of its use in a recent phosphoproteomic study authored by scientists from CST.
Overview of Cellular Metabolism pathways, antibodies and related reagents, interactive pathway diagrams, and other technical resources
Cell Signaling Technology pathways by research area
We review a recent paper that links TREM2 to microglial function in combatting amyloid plaques, potentially suggesting new targets for Alzheimer's research.
Expert-reviewed interactive pathway providing a current overview of ErbB/HER Signaling.
A scientific resource for the HEAT protein domain containing information on structure, function, and domain binding.
Video Tutorial on PI3K / Akt Signaling created by CST on upstream stimuli and downstream effects on cellular events (autophagy, mTOR)
CST sponsored Science Webinar Series: Metabolic Changes in Cancer: April 19, 2012. Hear the webinar (3 speakers), download slides and transcripts.
