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Explore the NFkB pathway and its impact on inflammation and immune responses. Click here to learn more about this signaling pathway.
Find Pathways and Diagrams By Disease Area
Explore the complex inflammation signaling pathways. Click here to learn more and understand the molecular basis of inflammation.
Expert-reviewed interactive diagram of Rheumatoid Arthritis Pathogenesis and relevant antibodies for studying targets associated with the autoimmune disease.
Resources include signaling pathways, antibodies and companion products, research overviews, technical resources, and recent review articles.
Case Study 4: Exceptional Performance of XP Monoclonal Antibodies from Cell Signaling Technology.
Cancer cells hijack inflammatory mechanisms to promote their own growth and survival.
Alphabetical listing of protein, pathway, and antibody acronyms, curated by Cell Signaling Technology.
Expert-reviewed interactive pathway providing a current overview of the Inflammasome Signaling Pathway.
"PI3K/Akt signaling is close to my heart because certain diseases that have cropped up in my family are linked to specific proteins in this pathway."
Products and Related Resources for Virus Detection and Innate Immune Activation SARS-CoV-2 Research
Learn about BCR signaling and how it can lead to changes in cell metabolism, gene expression, and cytoskeletal organization. Click here.
SimpleChIP Kits and Antibodies validated in-house by our antibody development scientists correlated to positive and negative control primers.
Lymphoma is a cancer of the lymphatic system, a key part of the body’s immune system. Treatment options & patient prognoses differ based on lymphoma type.
Identifies and quantifies up to many hundreds of critical signaling nodes across pathways involved in cancer biology, immune cell signaling, and more.
Information and case study data for the PTMScan Direct Apoptosis/Autophagy Service offered by CST.
Melanomas account for 90% of skin cancer deaths. A big contributor to this: the lack of effective, durable treatments for unresectable, metastatic melanoma.
Proteomics can help elucidate mitochondrial homeostasis and dysfunction, inflammasome activation, and the role of parkin in Parkinson's disease.
Learn here about the HIF-1 signaling pathway and its impact on oxygen homeostasis and cellular adaptation. Click here.
Information and case study data for the PTMScan Direct PI3K/Akt Service offered by CST, which allows for targeted screening of 105 proteins within the Akt pathway.
Study the ubiquitin proteasome pathway and its critical role in protein degradation and cellular homeostasis. Expert reviewed pathways.
Products and Related Resources for Cytokines and Inflammation SARS-CoV-2 Research
Learn how CUT&RUN can be performed in as little as 1-2 days using low cell number samples, and how CUT&RUN has been employed to study epigenetic remodeling and alternative splicing directed by the NF-κB pathway downstream of a viral oncoprotein.
Expert-reviewed interactive pathway providing a current overview of Death Receptor Signaling.
Please refer to these links from the Gilmore Lab at Boston University, which list NFkB activators and inhibitors reported in the literature:
Activators: http://www.bu.edu/nf-kb/physiological-mediators/inducers/
Inhibitors: http://www.bu.edu/nf-kb/physiological-mediators/inhibitors/
Expert-reviewed interactive pathway providing a current overview of TLR signaling.
Discover the PI3K Akt pathway and its crucial role in cell growth and survival. Click here to learn more & gain insights into this important signaling cascade
Researchers are still working hard to develop effective treatments for SARS-CoV-2 and COVID-19.
Cell Signaling Technology pathways by research area
