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A scientific resource for the TUDOR protein domain containing information on structure, function, and domain binding to methylated-lysine residues in chromatin remodeling.
Interested in studying senescence? Understanding cell cycle arrest is critical to many fields of research, including development, aging, and cancer.
Information and case study data for the PTMScan Direct Cell Cycle and DNA Damage Service offered by CST.
A scientific resource for the BRCT protein domain containing information on structure, function, and binding to phospho-serine motifs.
Senescence is the irreversible arrest of proliferation in response to a variety of cellular stressors. This state is associated with changes in intracellular signaling pathways. Learn more.
Expert-reviewed interactive pathway providing a current overview of Histone Methylation.
Cellular senescence is defined by permanent cell cycle arrest. Senescent cells accumulate with age and contribute to normal aging and age-related disorders
The specificity of our 4E-BP1 (53H11) Rabbit mAb #9644 has been confirmed as follows:1) See “Western blot analysis of extracts from control HeLa cells (Lane 1) or HeLa cells with a targeted mutation in the gene encoding 4E-BP1 (Lane 2)” on the product webpage at https://www.cellsignal.com/products/primary-antibodies/4e-bp1-53h11-rabbit-mab/9644.2) 4E-BP1/2 DKO MEFs PMID: 28918902 (https://pubmed.ncbi.nlm.nih.gov/28918902/) Figure 6E
The Ubiquitin Ligase Table provides a comprehensive list of E3 ubiquitin ligases along with their substrates and corresponding PubMed reference(s).
Explore the mitochondrial apoptosis pathway and its role in programmed cell death. Read more about this essential pathway here.
The Histone Modification Table provides a referenced list of many known histone modifications, associated modifying enzymes, and proposed functions.
List of publications based on primary research done by the Cancer Research Group at CST (2002-2013).
Resources for the study of Translational Control, Protein Synthesis, and RNA Regulation including antibodies and associated reagents and interactive pathway diagrams.
Alphabetical listing of protein, pathway, and antibody acronyms, curated by Cell Signaling Technology.
Fostering mentorship, application-based learning, and a love of science are all part of the mission of the CST internship program. Students interning with us are partnered with CST Mentors.
Learn how RNA-binding proteins influence RNA regulation and epitranscriptomics and contribute to the progression of a variety of diseases.
Find validated CST® matched antibody pairs and streamline the development of your High-Throughput ELISA-Like Immunoassays for screening.
The PI3K / Akt Substrates Table provides a comprehensive list of demonstrated downstream targets of Akt phosphorylation.
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
A scientific resource for the ANK protein domain containing information on structure, function, and binding partners.
