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Expert-reviewed interactive pathway providing a current overview of protein ubiquitination and proteasome degradation, as well as links to products from Cell Signaling Technology.
Study the intricate cell cycle pathway's regulation of cell division and proliferation. Learn more here.
This post summarizes the findings in the Nature paper YAP-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer.
Interact with this signaling pathway showing immune checkpoint regulation in the tumor microenvironment, including targets such as PD-L1, GITR, TIM-3, CTLA-4, OX40, and more.
Download the Antibody Staining Guide for Flow Cytometry to help demystify the antibody staining process and guide you through assay set-up step-by-step.
Why not take advantage of our own immune system and the best of its weaponry, the T-cells, to fight cancer? This is the basis of immunotherapy.
Explore the intricate Wnt Beta Catenin pathway & its role in cell development and disease. Learn more about the signaling cascade of this crucial pathway.
A scientific resource for the RING protein domain containing information on structure, function, and domain binding to ubiquitin in protein degradation pathways.
Expert-reviewed interactive pathway providing a current overview of Cell Cycle G1/S Checkpoint Signaling.
A scientific resource for the ARM protein domain containing information on structure, function, and domain binding.
A scientific resource for the ADF protein domain containing information on structure, function, and binding to monomeric and filamentous actin.
CST offers a growing portfolio of products for the study of immune checkpoint targets in cancer, including several receptor-ligand pairs.
The Ubiquitin Ligase Table provides a comprehensive list of E3 ubiquitin ligases along with their substrates and corresponding PubMed reference(s).
Expert-reviewed interactive pathway providing a current overview of Regulation of Microtubule Dynamics.
Validation for flow cytometry antibodies from CST Cell Signaling Technology
Summary of human oncogenes and tumor suppressor genes sorted by signaling pathway.
To perform intracellular flow cytometry, fixation and permeabilization of cells is required to allow for antibody penetration and subsequent binding to targets without disrupting cellular morphology.
Use our protocol compatibility table to understand which immune signaling and phenotyping antibodies will work together in your multicolor flow cytometry experiment.
Custom-build antibody conjugates that match your assay requirements and deliver superior performance, and choose from a broad catalog of labels.
Rapid-act anti-CD3/CD28 T cell activation and expansion kits stimulate activation in one step for studying early and/or short-lived signaling events.
Learn more about how intracellular flow cytometry can be used to measure unique signaling events to do with apoptosis, pluripotency status and epigenetic activity.
Discover the power of flow cytometry in cellular analysis and biomarker detection. Click here to learn more
Troubleshooting tips for successfully performing Intracellular Flow Cytometry using CST recommended protocols and antibodies validated for Flow.
Alphabetical listing of protein, pathway, and antibody acronyms, curated by Cell Signaling Technology.
The adaptive immune response uses antigen-specific receptors to detect foreign antigens with help from T cells, B cells, and NK T cells.
Learn about the antibodies, custom reagents, and ready-to-use cell assay kits to support your CAR-T therapy development.
Streamline your oncology therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
The immune system is composed of tissues, cells, and molecules whose primary function is to detect, respond to, and eliminate pathogens and transformed cells.
Learn more about stem cell pathways and the transcription factors Oct-4, Sox2, and Nanog are essential for maintaining the pluripotent state of stem cells.
Expert-reviewed signaling pathway providing a current overview of adherens junction dynamics and links to products by Cell Signaling Technology.
