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A scientific resource for the BH protein domains containing information on structure, function, and domain binding in apoptosis.
The accuracy of western blot results relies heavily on the quality of the primary antibody used. CST™ antibodies are validated using multiple experiments.
Overview of apoptosis signaling networks, antibodies and related reagents, interactive pathway diagrams, and technical resources for apoptosis research.
Explore the mitochondrial apoptosis pathway and its role in programmed cell death. Read more about this essential pathway here.
Expert-reviewed interactive pathway providing a current overview of Inhibition of Apoptosis Signaling.
Information and case study data for the PTMScan Direct Apoptosis/Autophagy Service offered by CST.
Regulation of cell death due to viral infection is important for host survival. In this series, we look at pathways regulated through cellular responses to viruses.
Products and Related Resources for Cell Death and Viability SARS-CoV-2 Research
Recent advancements including next-generation proteasome inhibitors, monoclonal bispecific antibodies, antibody-drug conjugates, and CAR-T therapies that have changed the therapeutic landscape for multiple myeloma.
Senescence is the irreversible arrest of proliferation in response to a variety of cellular stressors. This state is associated with changes in intracellular signaling pathways. Learn more.
Apoptosis is a regulated form of programmed cell death (PCD) that occurs without external influence.
A scientific resource for the 14-3-3 protein domain containing information on structure, function, and binding to phospho-serine and phospho-threonine motifs.
Streamline your oncology therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
The regulation of ER stress and autophagy during viral infection is an important factor in the balance of virus and host survival.
Expert-reviewed interactive pathway providing a current overview of Death Receptor Signaling.
A scientific resource for the PDZ protein domain containing information on structure, function, and domain binding.
A scientific resource for the BTB/POZ protein domain containing information on structure, function, and domain binding during chromatin remodeling.
Cell states can be monitored using markers correlating to your process of interest. These assays and antibodies can be used to detect cell viability, senescence, proliferation, apoptosis, cytotoxicity and oxidative state.
Apoptosis is a highly regulated form of programmed cell death that occurs in multicellular organisms throughout life and in response to cellular stress.
Use our protocol compatibility table to understand which immune signaling and phenotyping antibodies will work together in your multicolor flow cytometry experiment.
Lymphoma is a cancer of the lymphatic system, a key part of the body’s immune system. Treatment options & patient prognoses differ based on lymphoma type.
Discover the autophagy pathway and its crucial role in cellular homeostasis. Learn more and uncover the mechanisms of cellular self-degradation here.
Cancer cells resist inhibitory signals that might otherwise stop their growth. The major pathways involved are Autophagy and Apoptosis.
Cancer cells can resist death. They evade apoptosis, the mechanism that programs cell death once cells become damaged. Normally, apoptosis helps keep an organism healthy through growth and development, but cancer cells do not follow this process, no matter how abnormally they grow.
The PI3K / Akt Substrates Table provides a comprehensive list of demonstrated downstream targets of Akt phosphorylation.
Alphabetical listing of protein, pathway, and antibody acronyms, curated by Cell Signaling Technology.
List of publications based on primary research done by the Cancer Research Group at CST (2002-2013).
Lymphoid lineage cells can be characterized using antibodies for cell type-specific markers, allowing cells to be visualized using flow cytometry or IHC.
SimpleChIP Kits and Antibodies validated in-house by our antibody development scientists correlated to positive and negative control primers.