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A scientific resource for the F-Box protein domain containing information on structure, function, and domain binding to ubiquitin in protein degradation pathways.
Alphabetical listing of protein, pathway, and antibody acronyms, curated by Cell Signaling Technology.
Study the ubiquitin proteasome pathway and its critical role in protein degradation and cellular homeostasis. Expert reviewed pathways.
Expert-reviewed interactive signaling pathways providing current overviews of the regulation of actin and microtubule dynamics, as well as links to products from CST.
The Ubiquitin Ligase Table provides a comprehensive list of E3 ubiquitin ligases along with their substrates and corresponding PubMed reference(s).
The PI3K / Akt Substrates Table provides a comprehensive list of demonstrated downstream targets of Akt phosphorylation.
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
Kinase-disease associations table showing kinases, kinase groups, disease types, and the molecular biology basis for disease.
A chronological listing of case studies and peer-reviewed publications utilizing PTMScan proteomic technology developed by Cell Signaling Technology.
A scientific resource for the WD40 protein domain containing information on structure, function, and binding to both phospho-Ser/Thr and methylated lysine residues.
A list of important CD markers that includes links to PhosphoSitePlus, Uniprot, and products from Cell Signaling Technology.
A scientific resource for the PB1 protein domain containing information on structure, function, and domain binding in cytoskeletal signaling proteins.
Overview of GPCR, Calcium, cAMP Signaling Resources, interactive pathway diagrams, and other technical resources.
B cells are lymphocytes that are an important part of the humoral immune response. The main role of B cells is to produce antibodies in response to antigens.
Information and case study data for the PTMScan Direct Cell Cycle and DNA Damage Service offered by CST.
Activation of signaling networks downstream of B-cell receptors leads to altered B-cell phenotypes, which can be identified by cellular markers.
CST offers a growing portfolio of products for the study of immune checkpoint targets in cancer, including several receptor-ligand pairs.
Why not take advantage of our own immune system and the best of its weaponry, the T-cells, to fight cancer? This is the basis of immunotherapy.
The Akt Binding Partners Table provides a list of proteins that bind to Akt along with their effects, activities, and corresponding PubMed reference(s).
Advancements in immunotherapeutics against cancer include receptor agonists, adoptive cell transfer, anti-cancer vaccines, and combination therapies.
Necrosis has been classically defined as an unprogrammed form of cell death that occurs in response to overwhelming chemical or physical insult.
Expert-reviewed interactive pathway providing a current overview of Inhibition of Apoptosis Signaling.
The ESC and Lineage Markers diagram provides an overview of ESC differentiation along lineage-specific pathways and links to products from CST.