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Information and case study data for the PTMScan Direct Tyrosine Kinases Service from Cell Signaling Technology.
Kinase-disease associations table showing kinases, kinase groups, disease types, and the molecular biology basis for disease.
List of publications based on primary research done by the Cancer Research Group at CST (2002-2013).
Learn more about stem cell pathways and the transcription factors Oct-4, Sox2, and Nanog are essential for maintaining the pluripotent state of stem cells.
DIY conjugation kits let researchers label an antibody themselves but lengthy protocols, poor conjugate quality and low yield cause inconsistent results.
Find validated CST® matched antibody pairs and streamline the development of your High-Throughput ELISA-Like Immunoassays for screening.
What if an antibody could identify a PTM, regardless of the flanking amino acid sequence? This innovative idea is the basis of CST's PTMScan product line.
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
A chronological listing of case studies and peer-reviewed publications utilizing PTMScan proteomic technology developed by Cell Signaling Technology.
While FGF Receptor 2 can migrate at the predicted 92 kDa, due to post-translational N-linked glycosylation at 8 predicted sites, it is often observed at greater than 140 kDa (see https://www.uniprot.org/uniprot/P21802). This variability in migration (for FGFR1, 2, and 3) has been experimentally validated in the literature, often by treating samples with glycosylation inhibitors:Keegan, K. et al. (1991) Oncogene 6, 2229-36 (PMID: 1662791, https://www.ncbi.nlm.nih.gov/pubmed/1662791)Hatch, N.E. et al. (2006) J Biol Chem. 281, 27292-305 (PMID: 16844695; https://www.ncbi.nlm.nih.gov/pubmed/16844695)