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Information and case study data for the PTMScan Direct PI3K/Akt Service offered by CST, which allows for targeted screening of 105 proteins within the Akt pathway.
Discover the insulin signaling pathway and its role in glucose metabolism & diabetes. Learn more about insulin action here.
Expert-reviewed interactive pathway providing a current overview of Inhibition of Apoptosis Signaling.
Expert-reviewed interactive pathway providing a current overview of Cell Cycle G1/S Checkpoint Signaling.
Necrosis has been classically defined as an unprogrammed form of cell death that occurs in response to overwhelming chemical or physical insult.
Study the intricate machinery of the apoptosis signaling pathway. Click here to learn more and gain insights into programmed cell death mechanisms.
The PI3K / Akt Substrates Table provides a comprehensive list of demonstrated downstream targets of Akt phosphorylation.
"PI3K/Akt signaling is close to my heart because certain diseases that have cropped up in my family are linked to specific proteins in this pathway."
Overview of PI3K/Akt signaling pathways, antibodies and related reagents, interactive pathway diagrams, and other technical resources.
A journal club article elucidating the mechanisms of beta cell failure leading to type 2 diabetes.
The Ubiquitin Ligase Table provides a comprehensive list of E3 ubiquitin ligases along with their substrates and corresponding PubMed reference(s).
Learn about BCR signaling and how it can lead to changes in cell metabolism, gene expression, and cytoskeletal organization. Click here.
A Hallmark of Cancer, sustaining proliferative signaling is used by cancer cells to stimulate growth and relies on Akt, MAPK/Erk, and MTOR pathways.
Apoptosis is a highly regulated form of programmed cell death that occurs in multicellular organisms throughout life and in response to cellular stress.
Roughly 1 in 8 men will be diagnosed with prostate cancer. So why do so many men lose their battle? Emerging therapeutic options may turn this around.
Discover the PI3K Akt pathway and its crucial role in cell growth and survival. Click here to learn more & gain insights into this important signaling cascade
Explore the G protein coupled receptor signaling pathway and its diverse roles in cellular communication. Read more here.
Summary of human oncogenes and tumor suppressor genes sorted by signaling pathway.
Explore the ERK pathway and its role in cell proliferation and survival. Click here to read more about this critical signaling pathway.
SimpleChIP Kits and Antibodies validated in-house by our antibody development scientists correlated to positive and negative control primers.
The ESC and Lineage Markers diagram provides an overview of ESC differentiation along lineage-specific pathways and links to products from CST.
