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Information and case study data for the PTMScan Direct Cell Cycle and DNA Damage Service offered by CST.
Interactive p38 MAPK pathway. Learn how p38 MAPK is involved in regulation of HSP27, MAPKAPK-2, MAPKAPK-3, & several transcription factors.
Information and case study data for the PTMScan Direct Ser/Thr Kinases Service, which allows for the targeted screening of a defined set of protein modification sites.
Overview of MAP Kinase signaling pathways, antibodies and related reagents, interactive pathway diagrams, and other technical resources.
Expert-reviewed interactive pathway providing a current overview of angiogenesis pathways and links to products by Cell Signaling Technology.
Learn more about commonly used chemical modulators to study cellular physiology and biology.
Products and Related Resources for Cytokines and Inflammation SARS-CoV-2 Research
Expert-reviewed interactive pathway providing a current overview of TLR signaling.
Expert-reviewed interactive pathway providing a current overview of ErbB/HER Signaling.
Cell Signaling Technology pathways by research area
A list of important CD markers that includes links to PhosphoSitePlus, Uniprot, and products from Cell Signaling Technology.
Explore the NFkB pathway and its impact on inflammation and immune responses. Click here to learn more about this signaling pathway.
As a new antibody is developed, Cell Signaling Technology scientists test the antibody’s stability and activity
Identifies and quantifies up to many hundreds of critical signaling nodes across pathways involved in cancer biology, immune cell signaling, and more.
Catalog numbers in tabular format for control cell extracts and proteins with links to product pages.
We apologize for any confusion regarding our EGF Receptor (D38B1) XP® Rabbit mAb #4267 and its recommendation for IHC on human tissue only. The species reactivity at the top of the web page is determined by western blot. We have tested this clone on mouse tissue by IHC and found that it does not work very well despite being an excellent tool for the analysis of human tissue. For this reason, we added a note to the product's web page and datasheet under Sensitivity/Specificity indicating that for IHC and IF the species reactivity is human only. We would instead suggest our EGF Receptor (D1P9C) Rabbit mAb (Mouse Preferred) #71655 for use with mouse tissues.
Interested in studying senescence? Understanding cell cycle arrest is critical to many fields of research, including development, aging, and cancer.
Case Study 4: Exceptional Performance of XP Monoclonal Antibodies from Cell Signaling Technology.
A demonstration of the perils of deviating from Cell Signaling Technology's recommended protocols.
Discover the TGF Beta signaling pathway and impact on cell growth & tissue homeostasis. Learn here the mechanisms behind this vital signaling cascade.
Phospho-Erk product lists, product citation lists, product selection tools, comparison tables and educational resources for MAPK signaling from Cell Signaling Technology.
YAP is a critical mediator of the Hippo signaling pathway. See a performance comparison of YAP antibodies from CST and 2 other companies.
Products and Related Resources for Adaptive Immune Response SARS-CoV-2 Research
Learn how to visualize protein expression in tissue with immunohistochemistry (IHC). See examples of successfully optimized IHC assays.
Cellular senescence is stable cell cycle arrest linked to aging and cancer and other disease states, including those associated with inflammation. It is induced by DNA damage, oncogenic signaling, and telomere shortening.
The accuracy of western blot results relies heavily on the quality of the primary antibody used. CST™ antibodies are validated using multiple experiments.
Numerous p53 splice variants have been documented in the literature. They arise from alternative splicing of p53 transcripts and result in multiple isoforms. UniProt for the human sequence (UniProt P04637) lists 9 isoforms produced by alternative promoter usage and alternative splicing and there may be more, depending on the model. Some of these splice variants are associated with polymorphisms or mutations of the p53 genes. Isoform 1 (43.6 kDa) is predominant. However isoform 2 (37.8 kDa) and isoform 3 (38.5 kDa) are also well documented. The combination of p53 cleavage and alternative splicing allows for a diverse size-range of p53 proteins, however, the study of p53 degradation has focused largely on the canonical full-length isoform 1. Also note that the proline-rich region of p53 slows the migration of p53 in SDS-PAGE gels, increasing the apparent molecular weight of the p53 isoforms that express it. [see M.P. Khoury and J.C. Bourdon. (2010) Cold Spring Harb Perspect Biol. 2(3):a000927, Review (PMID: …
A number of growth factors and cytokines can induce an Epithelial-Mesenchymal Transition (EMT) in tumor cells.
