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Information and case study data for the PTMScan Direct Tyrosine Kinases Service from Cell Signaling Technology.
PDGF Receptor α (PDGFRa) contains a signal peptide consisting of the first 23 amino acids of the protein sequence. Mature PDGFRa does not contain this signal peptide and it is possible to see a doublet representing both forms; the lower form being the mature protein. This protein is also heavily glycosylated and thus the apparent molecular weight exceeds that of the predicted molecular weight based on amino acid sequence.
Mass spectrometry-based proteomic methods like PTMScan can be applied in translational research. For example to identify novel biomarkers of disease
Expert-reviewed interactive pathway providing a current overview of ErbB/HER Signaling.
Kinase-disease associations table showing kinases, kinase groups, disease types, and the molecular biology basis for disease.
A list of important CD markers that includes links to PhosphoSitePlus, Uniprot, and products from Cell Signaling Technology.
Overview of Angiogenesis antibodies & related reagents, interactive pathway diagrams, and other technical resources.
The Jak/Stat Utilization Table displays the combinatorial use of tyrosine kinases and Stat proteins in cytokine/growth factor signaling.
Learn more about commonly used chemical modulators to study cellular physiology and biology.
Synopsis of CST scientists' publication in the journal Science Signaling describing phosphorylation patterns associated with non-small cell lung cancer (NSCLC).
This video introduces PTMScan technology, a platform for the enrichment of post-translational modifications (PTMs) in mass spectrometry-based proteomics studies.
A video tutorial illustrating the methodology behind PTMScan Technology and an example of its use in a recent phosphoproteomic study authored by scientists from CST.
Angiogenesis, the formation of new blood vessels from pre-existing blood vessels, plays a key role in tumorigenesis.
Exactly what is ELISA? Learn about the enzyme-linked immunosorbent assay, the specific interaction between antibody & antigen. Click here.
Melanomas account for 90% of skin cancer deaths. A big contributor to this: the lack of effective, durable treatments for unresectable, metastatic melanoma.
A scientific resource for the SH2 protein domain containing information on structure, function, and domain binding to phospho-tyrosine motifs.
Find validated CST® matched antibody pairs and streamline the development of your High-Throughput ELISA-Like Immunoassays for screening.
Phospho-Erk product lists, product citation lists, product selection tools, comparison tables and educational resources for MAPK signaling from Cell Signaling Technology.
List of publications based on primary research done by the Cancer Research Group at CST (2002-2013).
Expert-reviewed interactive pathway providing a current overview of angiogenesis pathways and links to products by Cell Signaling Technology.
Researchers are still working hard to develop effective treatments for SARS-CoV-2 and COVID-19.
Cancer cells stimulate the growth of blood vessels to supply nutrients to tumors. Angiogenesis is the formation of new blood vessels from pre-existing blood vessels. This plays an important role in tumor growth.
Learn here about the HIF-1 signaling pathway and its impact on oxygen homeostasis and cellular adaptation. Click here.
Expert-reviewed diagram providing a current overview of the Mechanisms of Fibrosis pathway with references to its role in adhesion
How does the choice of blocking protein—nonfat dry milk vs bovine serum albumen (BSA)—affect your western blot (WB) results? Watch the Tech Tips video.
Streamline your oncology therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
A chronological listing of case studies and peer-reviewed publications utilizing PTMScan proteomic technology developed by Cell Signaling Technology.
