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Expert-reviewed interactive pathway providing a current overview of Hippo Signaling.
Explore the mitochondrial apoptosis pathway and its role in programmed cell death. Read more about this essential pathway here.
Expert-reviewed interactive pathway providing a current overview of PTM Crosstalk Signaling.
Explore the ERK pathway and its role in cell proliferation and survival. Click here to read more about this critical signaling pathway.
Expert-reviewed interactive pathway providing a current overview of Cell Cycle G2/M DNA Damage Signaling.
Study the intricate cell cycle pathway's regulation of cell division and proliferation. Learn more here.
Study the intricate machinery of the apoptosis signaling pathway. Click here to learn more and gain insights into programmed cell death mechanisms.
Expert-reviewed interactive pathway providing a current overview of SAPK/JNK Signaling.
A scientific resource for the 14-3-3 protein domain containing information on structure, function, and binding to phospho-serine and phospho-threonine motifs.
Expert-reviewed interactive pathway providing a current overview of T Cell Receptor (TCR) Signaling.
The PI3K / Akt Substrates Table provides a comprehensive list of demonstrated downstream targets of Akt phosphorylation.
For antigenic targets where expression of the protein is very low or unknown, the use of recombinant proteins or exogenous expression in a surrogate cell line may be necessary for antibody validation.
A categorical list of protein domain resources by Cell Signaling Technology. Each resource contains specific domain structure, function, and binding information.
Validation using recombinant proteins or exogenous expression in a surrogate cell line can be used for targets with low levels of protein expression.
KinomeView® Profiling Kit and Services
Expert-reviewed interactive pathway providing a current overview of Cell Cycle G1/S Checkpoint Signaling.
Expert-reviewed interactive pathway providing a current overview of Contribution of Extracellular Matrix to EMT Signaling.
Interact with this CAR-T signaling pathway to learn how the combination of extracellular and intracellular domains, including CD8, CD28, 4-1BB, OX40, or CD27, exert antitumor effects.
Expert-reviewed interactive pathway providing a current overview of Translational Control.
This post explores common T cell types, their roles in modulating immune cell response, and T cell activation via interaction with cell surface receptors.
PhosphoScan® Phosphorylation Proteomics
Expert-reviewed signaling pathway providing a current overview of adherens junction dynamics and links to products by Cell Signaling Technology.
Immunohistochemistry (IHC) is a powerful technique. Learn how to perform IHC on paraffin sections with our step-by-step IHC protocol. Click here.
Interact with this diagram showing the epigenetic regulators of Histone H3 including those responsible for monomethylation, asymmetric and symmetric dimethylation, and trimethylation.
Explore the complex inflammation signaling pathways. Click here to learn more and understand the molecular basis of inflammation.
The Histone Modification Table provides a referenced list of many known histone modifications, associated modifying enzymes, and proposed functions.
Immunohistochemistry Protocol (Paraffin): easy to follow directions describing the step by step experimental procedure.
Immunohistochemistry Protocol (Paraffin) - Specific for Product: easy to follow directions describing the step by step experimental procedure.
The official blog of Cell Signaling Technology, where we discuss what to expect from your time at the bench and share tips, tricks, and information.
Discover the PI3K Akt pathway and its crucial role in cell growth and survival. Click here to learn more & gain insights into this important signaling cascade
