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The regulation of ER stress and autophagy during viral infection is an important factor in the balance of virus and host survival.
Products and Related Resources for Cell Death and Viability SARS-CoV-2 Research
The antigenic sequence used to produce our ATF-6 (D4Z8V) Rabbit mAb #65880 is located at the C-terminus of ATF-6, so this product may recognize a C-terminal fragment. However, our testing has shown that #65880 does not detect a cleavage product after stimulating ER-stress with an extended tunicamycin treatment (i.e., 8 hours).
Catalog numbers in tabular format for control cell extracts and proteins with links to product pages.
Products and Related Resources for Virus Detection and Innate Immune Activation SARS-CoV-2 Research
The product webpage for our ATF-6 (D4Z8V) Rabbit mAb #65880 shows a molecular weight shift from 100 kDa to 90 kDa following treatment with tunicamycin, an agent which induces ER stress. The short, 1 hour tunicamycin treatment shown on the webpage is sufficient to inhibit glycosylation without inducing ER-stress. Therefore, the observed molecular weight shift is due to deglycosylation of ATF-6.
Interactive p38 MAPK pathway. Learn how p38 MAPK is involved in regulation of HSP27, MAPKAPK-2, MAPKAPK-3, & several transcription factors.
Expert-reviewed interactive pathway providing a current overview of Regulation of eIF2.
CUT&Tag Frequently Asked Questions (FAQs) from Cell Signaling Technology, Inc.
The Histone Modification Table provides a referenced list of many known histone modifications, associated modifying enzymes, and proposed functions.
Alphabetical listing of protein, pathway, and antibody acronyms, curated by Cell Signaling Technology.
A Hallmark of Cancer, sustaining proliferative signaling is used by cancer cells to stimulate growth and relies on Akt, MAPK/Erk, and MTOR pathways.
SimpleChIP Kits and Antibodies validated in-house by our antibody development scientists correlated to positive and negative control primers.
Illustration of Motif Antibody Coverage
PTMScan Motif Antibody Kits from Cell Signaling Technology
Overview of apoptosis signaling networks, antibodies and related reagents, interactive pathway diagrams, and technical resources for apoptosis research.
A scientific resource for the BH protein domains containing information on structure, function, and domain binding in apoptosis.
The Calpain 2 Large Subunit (M-type) Antibody #2539 detects both active and inactive Calpain 2, which migrate at the same size (79-80 kDa). When Calpain 2 is autoproteolytically cleaved at Ser20, it can result in a 78 kDa band. Cleavage of Calpain 2 at serine 20 does not cause it to be activated; Calpain is only activated when it is bound to calcium.
Study the intricate cell cycle pathway's regulation of cell division and proliferation. Learn more here.
Compare Cell Signaling Technology's Erk antibodies against one another to determine optimal applications
Researchers are still working hard to develop effective treatments for SARS-CoV-2 and COVID-19.
Products and Related Resources for Fibrosis SARS-CoV-2 Research
To develop effective therapeutics and vaccines to fight the COVID-19 pandemic, solid experimental work using reliable, validated reagents and antibodies are as important as ever.
Immunohistochemistry Protocol (Paraffin): easy to follow directions describing the step by step experimental procedure.
Immunofluorescence Protocol with Gelatin Blocking Step: easy to follow directions describing the step by step experimental procedure.
Flow Cytometry BrdU Modified Protocol: easy to follow directions describing the step by step experimental procedure.
Immunoprecipitation Protocol (For Native Protein): easy to follow directions describing the step by step experimental procedure.
