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Information and case study data for the PTMScan Direct Cell Cycle and DNA Damage Service offered by CST.
Expert-reviewed interactive pathway providing a current overview of Cell Cycle G2/M DNA Damage Signaling.
Expert-reviewed interactive pathway providing a current overview of Cell Cycle G1/S Checkpoint Signaling.
The Akt Binding Partners Table provides a list of proteins that bind to Akt along with their effects, activities, and corresponding PubMed reference(s).
The Ubiquitin Ligase Table provides a comprehensive list of E3 ubiquitin ligases along with their substrates and corresponding PubMed reference(s).
The PI3K / Akt Substrates Table provides a comprehensive list of demonstrated downstream targets of Akt phosphorylation.
Necrosis has been classically defined as an unprogrammed form of cell death that occurs in response to overwhelming chemical or physical insult.
Checkpoint inhibitors, targeted antibodies, adoptive cell therapy, and cancer vaccines are promising immunotherapies with recent therapeutic developments.
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
A chronological listing of case studies and peer-reviewed publications utilizing PTMScan proteomic technology developed by Cell Signaling Technology.
Our Fc Block CD16/CD32 (2.4G2) Rat mAb #88280 binds to the Fc receptor on the surface of live cells and blocks the interaction of the Fc receptor with the Fc domain of antibodies. Preventing this interaction ensures that your antibodies will bind only to their intended target, rather than being sequestered by Fc receptors.
Kinase-disease associations table showing kinases, kinase groups, disease types, and the molecular biology basis for disease.
It is difficult to predict when the Fc receptor blocking step is necessary, due to the variable interaction of host species with different antibody isotypes and the interference caused by fluorescent dyes directly conjugated to the antibody Fc domain. The presence of these dyes is often sufficient to disrupt Fc receptor binding. If you are unable to conduct an experiment to assess nonspecific binding, we recommend using the CD16/CD32 (2.4G2) Rat mAb #88280 to prevent any unintended antibody binding to the Fc receptor.
Products and Related Resources for Virus Detection and Innate Immune Activation SARS-CoV-2 Research
This interactive guide shows the key cell and functional state markers for tumor-infiltrating immune cells in humans.Web Location: Immunology and Inflammation
CST offers a growing portfolio of products for the study of immune checkpoint targets in cancer, including several receptor-ligand pairs.
Use our protocol compatibility table to understand which immune signaling and phenotyping antibodies will work together in your multicolor flow cytometry experiment.