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Explore the intricate Wnt Beta Catenin pathway & its role in cell development and disease. Learn more about the signaling cascade of this crucial pathway.
ChIP-seq is a powerful technique that combines ChIP and next-generation sequencing (NGS) to study DNA-protein interactions across the entire genome, but it is only as good as the quality of the antibody used in the ChIP experiment.
Expert-reviewed interactive pathway providing a current overview of Cell Cycle G1/S Checkpoint Signaling.
Alphabetical listing of protein, pathway, and antibody acronyms, curated by Cell Signaling Technology.
SimpleChIP Kits and Antibodies validated in-house by our antibody development scientists correlated to positive and negative control primers.
A scientific resource for the HECT protein domain containing information on structure, function, and domain binding in ubiquitin-mediated protein degradation.
Study the intricate cell cycle pathway's regulation of cell division and proliferation. Learn more here.
A scientific resource for the RING protein domain containing information on structure, function, and domain binding to ubiquitin in protein degradation pathways.
A scientific resource for the UEV protein domain containing information on structure, function, and domain binding to ubiquitin.
A scientific resource for the UBA protein domain containing information on structure, function, and domain binding to ubiquitin in protein degradation pathways.
Cellular senescence is stable cell cycle arrest linked to aging and cancer and other disease states, including those associated with inflammation. It is induced by DNA damage, oncogenic signaling, and telomere shortening.
Expert-reviewed interactive pathway providing a current overview of protein ubiquitination and proteasome degradation, as well as links to products from Cell Signaling Technology.
Overview of autophagy signaling, antibodies and related reagents, interactive pathway diagrams, and technical resources for autophagy research.
A scientific resource for the F-Box protein domain containing information on structure, function, and domain binding to ubiquitin in protein degradation pathways.
Discover the autophagy pathway and its crucial role in cellular homeostasis. Learn more and uncover the mechanisms of cellular self-degradation here.
A chronological listing of case studies and peer-reviewed publications utilizing PTMScan proteomic technology developed by Cell Signaling Technology.
Tissue clearing has paved the way for intact brain imaging with molecular phenotyping. The technology is rapidly evolving and shows great potential.
ER-phagy is one of the key processes that regulates endoplasmic reticulum morphology and functions in the fragmentation and removal of segments of the ER.
Interact with this diagram showing the epigenetic writers and erasers of histone H2A, histone H2B, and Histone H4, including the involvement of acetyltransferases, deacetylases, methyltransferases, demethylases and kinases.
Expert-reviewed interactive diagram of Rheumatoid Arthritis Pathogenesis and relevant antibodies for studying targets associated with the autoimmune disease.
Study the ubiquitin proteasome pathway and its critical role in protein degradation and cellular homeostasis. Expert reviewed pathways.
Richard discusses a recent paper that investigates the potential mechanistic link between the AD risk gene APOE4 and altered metabolism. This makes an interesting potential connection from diabetes to Alzheimer's.
Expert scientist-authored white paper focused on phosphorylation-dependent protein interaction domains in signal transduction.
The Ubiquitin Ligase Table provides a comprehensive list of E3 ubiquitin ligases along with their substrates and corresponding PubMed reference(s).
Kinase-disease associations table showing kinases, kinase groups, disease types, and the molecular biology basis for disease.
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.