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Highly specific and sensitive rabbit mAbs against B7 family targets, B7-H3 & B7-H4, are proven to outperform existing clones by WB.
Interact with this diagram showing the epigenetic writers and erasers of histone H2A, histone H2B, and Histone H4, including the involvement of acetyltransferases, deacetylases, methyltransferases, demethylases and kinases.
Resources include signaling pathways, antibodies and companion products, research overviews, technical resources, and recent review articles.
Find Pathways and Diagrams By Disease Area
A scientific resource for the MBT protein domain containing information on structure, function, and binding to methyl-lysine motifs during chromatin regulation.
The Histone Modification Table provides a referenced list of many known histone modifications, associated modifying enzymes, and proposed functions.
Overview of epigenetic and chromatin regulation pathways, antibodies and related reagents, interactive pathway diagrams, and technical resources for epigenetics research.
A scientific resource for the TUDOR protein domain containing information on structure, function, and domain binding to methylated-lysine residues in chromatin remodeling.
The predicted molecular weight of B7-H4 is 28.8 kDa, but by western blot it is usually observed at 40-80 kDa. This is due to glycosylation of the protein. It is common for a target to shift to higher molecular weights with post-translational modification (e.g., glycosylation). Please see Salceda, S. (2005) et al. Exp Cell Res. 306, 128-41 (PMID 15878339; http://www.ncbi.nlm.nih.gov/pubmed/15878339).
3D video animation of histone modifications and their effects on chromatin activation
A scientific resource for the BROMO protein domain containing information on structure, function, and binding to acetylated-lysine residues during chromatin remodeling.
CST offers a growing portfolio of products for the study of immune checkpoint targets in cancer, including several receptor-ligand pairs.
Why not take advantage of our own immune system and the best of its weaponry, the T-cells, to fight cancer? This is the basis of immunotherapy.
Histone modification antibodies are validated using a peptide array assay at CST
Cell Signaling Technology Announces the Release of a First to Market IHC-Approved VISTA Antibody
Learn how to visualize protein expression in tissue with immunohistochemistry (IHC). See examples of successfully optimized IHC assays.
Cell Signaling Technology pathways by research area
SimpleChIP Kits and Antibodies validated in-house by our antibody development scientists correlated to positive and negative control primers.
Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
Expert-reviewed interactive pathway providing a current overview of Histone Methylation.
Streamline your neurodegeneration therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
Find validated CST® matched antibody pairs and streamline the development of your High-Throughput ELISA-Like Immunoassays for screening.
Expert-reviewed interactive pathway providing a current overview of PTM Crosstalk Signaling.
The ESC and Lineage Markers diagram provides an overview of ESC differentiation along lineage-specific pathways and links to products from CST.
Immunohistochemistry is a method for studying antigen localization in tissue sections using antibodies. Learn sample preparation, labeling, & visualization.
Stem cell markers and kits organized in table format: links to product pages; includes Oct-4, Sox2, Nanog, c-Myc, C/EBPα, LIN28 and KLF4.
Use our protocol compatibility table to understand which immune signaling and phenotyping antibodies will work together in your multicolor flow cytometry experiment.
Immunofluorescence Protocol with Gelatin Blocking Step: easy to follow directions describing the step by step experimental procedure.
Immunofluorescence Protocol without Permeabilization: easy to follow directions describing the step by step experimental procedure.
Immunofluorescence Protocol for Biotin-Conjugated Antibodies: easy to follow directions describing the step by step experimental procedure.
