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Expert-reviewed interactive pathway providing a current overview of SAPK/JNK Signaling.
Expert-reviewed interactive pathway providing a current overview of Death Receptor Signaling.
Information and case study data for the PTMScan Direct Ser/Thr Kinases Service, which allows for the targeted screening of a defined set of protein modification sites.
As a new antibody is developed, Cell Signaling Technology scientists test the antibody’s stability and activity
Information and case study data for the PTMScan Direct Cell Cycle and DNA Damage Service offered by CST.
Expert-reviewed interactive pathway providing a current overview of TLR signaling.
Expert-reviewed interactive dopamine signaling pathway providing a current overview of Dopamine in Parkinson's Disease. Learn more here.
Expert-reviewed interactive pathway providing a current overview of T Cell Receptor (TCR) Signaling.
Study the IL-6 pathway and its impact on inflammation and immune regulation. Delve into the intricacies of this signaling cascade. Click here.
The Ubiquitin Ligase Table provides a comprehensive list of E3 ubiquitin ligases along with their substrates and corresponding PubMed reference(s).
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
Kinase-disease associations table showing kinases, kinase groups, disease types, and the molecular biology basis for disease.
Catalog numbers in tabular format for control cell extracts and proteins with links to product pages.
The PI3K / Akt Substrates Table provides a comprehensive list of demonstrated downstream targets of Akt phosphorylation.
The transcriptional activity of c-Jun is regulated by SAPK/JNK phosphorylation at Ser63 and Ser73. The signaling pathway can be found at https://www.cellsignal.com/contents/science-pathway-research-mapk-signaling/sapk-jnk-signaling-pathway/pathways-mapk-sapk. Cellular stressors, such as UV radiation, inflammatory cytokines, or ceramide, activate Rho-family GTPases and subsequent MAPKKK (Map Kinase Kinase Kinase) pathways. MAPKKKs can activate MKK4/7, which directly phosphorylate and activate SAPK/JNK. Upon translocation to the nucleus, SAPK/JNK can activate c-Jun and other transcription factors. Proteins generally undergo a phosphorylation dependent mobility shift (PDMS) in SDS-PAGE. This shift can vary from target to target, and even with different activation events on the same target. Recent experiments suggest this is due to the additional negative charge conferred by phosphorylation sites disrupting protein binding to SDS (see https://www.researchgate.net/publication/264031559_Phosphorylation-Depe…
Interactive p38 MAPK pathway. Learn how p38 MAPK is involved in regulation of HSP27, MAPKAPK-2, MAPKAPK-3, & several transcription factors.