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Non-neuronal cells like microglia and astrocytes play critical roles in maintaining proper neuronal function, development, and disease.
Therapeutic developments in treating Alzheimer’s, novel diagnostic tools, and new insights into neurodegeneration mechanisms were key topics at AD/PD 2023.
Please refer to these links from the Gilmore Lab at Boston University, which list NFkB activators and inhibitors reported in the literature:
Activators: http://www.bu.edu/nf-kb/physiological-mediators/inducers/
Inhibitors: http://www.bu.edu/nf-kb/physiological-mediators/inhibitors/
Expert-reviewed interactive signaling pathways providing current overviews of the regulation of actin and microtubule dynamics, as well as links to products from CST.
Summary of human oncogenes and tumor suppressor genes sorted by signaling pathway.
Products and Related Resources for Virus Detection and Innate Immune Activation SARS-CoV-2 Research
Explore the NFkB pathway and its impact on inflammation and immune responses. Click here to learn more about this signaling pathway.
Information and case study data for the PTMScan Direct Apoptosis/Autophagy Service offered by CST.
Information and case study data for the PTMScan Direct PI3K/Akt Service offered by CST, which allows for targeted screening of 105 proteins within the Akt pathway.
Expert-reviewed interactive pathway providing a current overview of Death Receptor Signaling.
Find Pathways and Diagrams By Disease Area
Cancer cells hijack inflammatory mechanisms to promote their own growth and survival.
Products and Related Resources for Cytokines and Inflammation SARS-CoV-2 Research
Learn how CUT&RUN can be performed in as little as 1-2 days using low cell number samples, and how CUT&RUN has been employed to study epigenetic remodeling and alternative splicing directed by the NF-κB pathway downstream of a viral oncoprotein.
Tissue clearing has paved the way for intact brain imaging with molecular phenotyping. The technology is rapidly evolving and shows great potential.
Expert-reviewed interactive diagram of Rheumatoid Arthritis Pathogenesis and relevant antibodies for studying targets associated with the autoimmune disease.
Resources include signaling pathways, antibodies and companion products, research overviews, technical resources, and recent review articles.
Expert-reviewed interactive pathway providing a current overview of T Cell Receptor (TCR) Signaling.
Explore the complex inflammation signaling pathways. Click here to learn more and understand the molecular basis of inflammation.
Proteomics can help elucidate mitochondrial homeostasis and dysfunction, inflammasome activation, and the role of parkin in Parkinson's disease.
Case Study 4: Exceptional Performance of XP Monoclonal Antibodies from Cell Signaling Technology.
Expert-reviewed interactive pathway providing a current overview of the Inflammasome Signaling Pathway.
A scientific resource for the TRAF protein domain containing information on structure, function, and domain binding in TNFR Signaling.
Catalog numbers in tabular format for control cell extracts and proteins with links to product pages.
A scientific resource for the F-Box protein domain containing information on structure, function, and domain binding to ubiquitin in protein degradation pathways.
Identifies and quantifies up to many hundreds of critical signaling nodes across pathways involved in cancer biology, immune cell signaling, and more.
Study the ubiquitin proteasome pathway and its critical role in protein degradation and cellular homeostasis. Expert reviewed pathways.
Alphabetical listing of protein, pathway, and antibody acronyms, curated by Cell Signaling Technology.