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Products and Related Resources for Viral Entry, Replication, and Transcription SARS-CoV-2 Research
Learn how RNA-binding proteins influence RNA regulation and epitranscriptomics and contribute to the progression of a variety of diseases.
The PI3K / Akt Substrates Table provides a comprehensive list of demonstrated downstream targets of Akt phosphorylation.
PhosphoScan® Phosphorylation Proteomics
KinomeView® Profiling Kit and Services
AcylScan™ - Acylation Proteomics
UbiScan® - Ubiquitination Proteomics
Listing of IHC-related scientific posters and papers involving scientists from Cell Signaling Technology.
List of publications based on primary research done by the Cancer Research Group at CST (2002-2013).
Identification of ALK and ROS1 fusion proteins in non-small cell lung cancer (NSCLC) at Cell Signaling Technology.
A chronological listing of case studies and peer-reviewed publications utilizing PTMScan proteomic technology developed by Cell Signaling Technology.
PTMScan Motif Antibodies and Kits, for customers who purchase a license and would like to perform PTMScan Proteomics in-house.
PTMScan® Sumoylation Remnant Motif Kit - SUMOylation Proteomics
PTMScan Motif Antibody Kits from Cell Signaling Technology
The Histone Modification Table provides a referenced list of many known histone modifications, associated modifying enzymes, and proposed functions.
MethylScan® - Methylation Proteomics
The PTMScan® HS Ubiquitin/SUMO Remnant Motif (K-ε-GG) Kit #59322 uses the same antibody as in the traditional PTMScan Ubiquitin Remnant Motif (K-ε-GG) Kit #5562 and PTMScan Pilot Ubiquitin Remnant Motif (K-ε-GG) Kit #14482. This means it has the same affinity for the K-e-GG remnant after trypsin cleavage.However, we have changed the antibody – bead linkage to be near-covalent in strength so the antibody does not contaminate the PTM peptides during the elution step. This prevents issues with the liquid chromatography column clogging and increases the yield of PTM peptides identified. The specificity is also improved with changes to the bind and wash buffers that help reduce non-specific peptide binding.In addition, the new HS kit beads are magnetic, rather than agarose, which simplifies the workflow by eliminating multiple centrifugation steps during the bead washing and elution steps.
CST supports environmental projects and science education by providing small grants to local organizations.
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
We have found that a doublet may appear if samples are boiled prior to gel loading when performing a western blot with our Na,K-ATPase Antibody #3010. The protein structure of this target is extremely sensitive to denaturing elements such as temperature, pH, ionic strength, presence of native lipids, cholesterol levels, and detergent concentration. We believe that the upper band is caused by protein aggregation due to this sensitivity and the location of the #3010 antigen in the transmembrane region of the protein. Therefore, we recommend omitting the boiling step during lysate preparation when using this antibody, which should eliminate the background band that sometimes appears above the target.
The Ubiquitin Ligase Table provides a comprehensive list of E3 ubiquitin ligases along with their substrates and corresponding PubMed reference(s).
The concentration of the antibody-beads included in the PTMScan® Ubiquitin Remnant Motif (K-ε-GG) Kit #5562 (Bead SKU #1990) is proprietary and therefore we are unable to disclose this information. We recommend using each vial as one assay.
Grant application guidelines and project description criteria for funding from CST.
Control peptides can be used to ensure reproducibility in proteomics experiments conducted with PTMScan.
Illustration of Motif Antibody Coverage
CSTs commitment to Science Education: teacher grants for scientific education resources and summer internship programs.
Expert-reviewed interactive pathway providing a current overview of the Inflammasome Signaling Pathway.
