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Information and case study data for the PTMScan Direct Cell Cycle and DNA Damage Service offered by CST.
Study the intricate cell cycle pathway's regulation of cell division and proliferation. Learn more here.
A scientific resource for the FHA protein domain containing information on structure, function, and binding to phospho-serine and phospho-threonine motifs.
Expert-reviewed interactive pathway providing a current overview of Cell Cycle G2/M DNA Damage Signaling.
A scientific resource for the POLO-Box protein domain containing information on structure, function, and domain binding to phospho-Ser/Thr motifs.
Summary of human oncogenes and tumor suppressor genes sorted by signaling pathway.
Information and case study data for the PTMScan Direct Ser/Thr Kinases Service, which allows for the targeted screening of a defined set of protein modification sites.
Not all cancer cells are equal, they evolve in response to selective pressure driven by accumulation of mutations.
Cancer cells can resist death. They evade apoptosis, the mechanism that programs cell death once cells become damaged. Normally, apoptosis helps keep an organism healthy through growth and development, but cancer cells do not follow this process, no matter how abnormally they grow.
Expert-reviewed interactive pathway providing a current overview of Cell Cycle G1/S Checkpoint Signaling.
Cellular senescence is stable cell cycle arrest linked to aging and cancer and other disease states, including those associated with inflammation. It is induced by DNA damage, oncogenic signaling, and telomere shortening.
The Ubiquitin Ligase Table provides a comprehensive list of E3 ubiquitin ligases along with their substrates and corresponding PubMed reference(s).
Streamline your oncology therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
List of publications based on primary research done by the Cancer Research Group at CST (2002-2013).
Kinase-disease associations table showing kinases, kinase groups, disease types, and the molecular biology basis for disease.
Find validated CST® matched antibody pairs and streamline the development of your High-Throughput ELISA-Like Immunoassays for screening.
Alphabetical listing of protein, pathway, and antibody acronyms, curated by Cell Signaling Technology.
Study the intricate machinery of the apoptosis signaling pathway. Click here to learn more and gain insights into programmed cell death mechanisms.
The ESC and Lineage Markers diagram provides an overview of ESC differentiation along lineage-specific pathways and links to products from CST.
The PI3K / Akt Substrates Table provides a comprehensive list of demonstrated downstream targets of Akt phosphorylation.
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
