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Discover the autophagy pathway and its crucial role in cellular homeostasis. Learn more and uncover the mechanisms of cellular self-degradation here.
Expert-reviewed interactive dopamine signaling pathway providing a current overview of Dopamine in Parkinson's Disease. Learn more here.
Cancer cells adapt mechanisms to evade death by hijacking mechanisms of immune checkpoint control and modulation of the innate immune response via STING.
Highly specific and sensitive rabbit mAbs against B7 family targets, B7-H3 & B7-H4, are proven to outperform existing clones by WB.
Mitophagy is a well-studied example of selective autophagy. This post explores mitophagy functions and the consequence of excessive or inadequate mitophagy
Autophagy is more than just the bulk degradation of intracellular components. It can also selectively degrade specific organelles, pathogens, and proteins.
Xenophagy provides an important defense against foreign pathogens such as bacteria and viruses by targeting them for degradation through autophagy.
Tissue clearing has paved the way for intact brain imaging with molecular phenotyping. The technology is rapidly evolving and shows great potential.
This webinar describes how highly validated antibodies and mouse models can be used to study neurodegenerative conditions like Alzheimer's Disease.
PTMScan Motif Antibody Kits from Cell Signaling Technology
Specificity, consistency, and optimized assay conditions are three key elements that help ensure reliable immunofluorescence (IF) staining results each and every time.
An antibody shouldn’t be one of the variables in your experiment. Find out why customers rank CST highest for antibody specificity and sensitivity.
Designing or troubleshooting flow cytometry experiments to analyze intracellular signaling? Here’s what you need to know.
Study the intricate machinery of the apoptosis signaling pathway. Click here to learn more and gain insights into programmed cell death mechanisms.
This webinar will focus on the potential role of innate immunity in neurodegeneration and cognitive function, particularly in Alzheimer's disease.
Cancer cells stimulate their own growth, which means they become self-sufficient in growth signals, and no longer depend on external signals (like Epidermal Growth Factor EGF/ EGFR). Proliferation depends highly on these three important pathways: Akt, MAPK/Erk, and MTOR.
Nov 2008, Renewal of a research agreement with Ortho-Biotech Oncology Research & Development, under which CST will employ its patented PhosphoScan® and PTMScan® technologies in research aimed at biomarker discovery and validation for multiple enzyme target classes and lead small-molecule inhibitors.
Oct 2007, CST announced the availability of PhosphoScan® profiling technology and PhosphoSite® knowledge base to academic researchers.
A scientific resource for the 14-3-3 protein domain containing information on structure, function, and binding to phospho-serine and phospho-threonine motifs.
Expert-reviewed interactive pathway providing a current overview of the molecular and cellular biology of Alzheimer’s Disease.
Lymphoid lineage cells can be characterized using antibodies for cell type-specific markers, allowing cells to be visualized using flow cytometry or IHC.
Discover the PI3K Akt pathway and its crucial role in cell growth and survival. Click here to learn more & gain insights into this important signaling cascade
Co-staining with multiple antibodies is a low-content form of multiplex analysis that be achieved using different host species or fluorophore conjugates.
Myeloid cells are differentiated from hematopoietic stem cells in the bone marrow and include monocytes, macrophages, neutrophils, basophils, eosinophils, erythrocytes, megakaryocytes, and platelets.
Will an antibody validated for WB perform as expected in an IF experiment? Here, we compare an IF-validated mAb from CST to one from another vendor.
PTMScan® Sumoylation Remnant Motif Kit - SUMOylation Proteomics
