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Associate Scientist/Scientist - Immunofluorescence

Danvers, MA

Cell Signaling Technology, Inc. (CST) is a worldwide leader in the development and commercialization of antibodies, assays and research tools. As a company of scientists for scientists, we have developed PTMScan®, a technology to discover protein post-translational modifications, PhosphoSitePlus®, an online resource for investigation of post-translational modifications, and XMT® technology, a proprietary method to develop exceptional monoclonal antibodies. We are fully committed to developing new research tools to help define the mechanisms underlying cell function and disease, thereby broadly accelerating progress in biomedical research and medicine.

We are currently seeking a highly motivated and detail-oriented bench scientist for a position within our Cytometry Group. The candidate will contribute to the innovation, development, and support of research tools, with a primary focus on characterizing antibodies by fluorescence microscopy. Successful candidates must thrive in a team environment, but have a proven track record of completing projects independently when provided with only high-level direction.


  • Independently analyze antibody performance in cell and tissue-based imaging assays. Techniques include both high-throughput, plate-based imaging, as well as traditional wide-field and high-resolution confocal microscopy.
  • Collaborate with senior project scientists to identify and develop cellular/tissue models that enable definitive characterization of antibody performance
  • Monitor literature, identify research/technology trends, and implement novel antibody approaches that yield imaging data relevant to modern user needs
  • Develop and optimize staining protocols for new antibody targets
  • Perform routine mammalian cell culture and tissue processing (including both frozen and paraffin-embedded samples)
  • Independently perform qualitative and quantitative data analyses, and communicate staining results to senior project scientists via presentation and email
  • Identify, analyze, and troubleshoot technical issues relating to antibody development and new lot QA/QC.
  • Provide support to colleagues in the commercial organization by reviewing datasheets and technical literature, generating scientific content for webinars and other marketing collateral, and hosting tech-training sessions for internal and external customers
  • Engage directly with customers who seek technical assistance via phone and email. Troubleshoot unexpected staining results and assist with experimental design questions while balancing commercial needs
  • Complete scientific and technical tasks on aggressive timelines, adapt to changing priorities, and manage a complex and varied target pipeline
  • May be required to coach junior staff members through questions of experimental design and data interpretation
  • The position is split between 60% bench work and 40% desk activities (e.g., data reporting, literature review, interfacing with customers, etc.)
  • May be required to travel to scientific conferences.


  • PhD graduate with a degree in biological sciences (e.g., cellular biology, immunology, oncology, or neuroscience) - no post-doc required
  • Previous experience with confocal microscopy, spectral imaging, immunofluorescence, immunohistochemistry, and/or HTS/HCS techniques
  • Experience developing and optimizing single and multiplex antibody-based fluorescence imaging assays
  • Hands-on experience with cell culture and tissue processing techniques
  • Working familiarity with signal transduction pathways and a broad knowledge of cellular markers
  • In-depth knowledge of the chemistry and molecular mechanisms driving common fixation, permeabilization, and antigen retrieval techniques
  • Proficiency in Microsoft Office is required, while a working familiarity with mainstream image processing software is a plus

Preferred Skills/Experience:

  • Enthusiastic and motivated collaborator with strong interpersonal skills
  • Good communication skills (written and oral) and the ability to work in a multidisciplinary team environment
  • A background in computer science, robotics, and/or lab automation is highly desired
  • Previous experience using gene editing tools (e.g., CRISPR/Cas9) and other protein silencing techniques
  • Recent experience with routine histopathological techniques and ASCP certification or eligibility is a bonus. Practical knowledge of major organ histology and the ability to identify structures and subtypes will be evaluated.


You will be taken to an external website, please attach your cover letter and resume as one document and refer to job code ASSCT/SCT-2016-R when applying.