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Download a Post Translational Modification of Amino Acids Poster

PTMScan® Direct PI3K/Akt Service allows access to perform targeted screening and quantification of a defined set of protein sites within the or related to the PI3K/ Akt pathway that are critical for drug discovery, biomarker discovery, or diagnostic development. The table below illustrates the list of protein sites that can be monitored with PTMScan® Direct PI3K/Akt Service.

Altogether, the PTMScan® Direct PI3K / Akt service provides a robust method to qualitatively identify and quantitatively profile 296 unique phosphorylation sites to 105 proteins.

PTMScan Direct PI3K/Akt Pathway Coverage.

PTMScan® Direct PI3K / Akt Service Sample Case Study Data

PTMScan® Direct PI3K / Akt Protein Sites

PI3K / Akt Protein Sites
PI3K / Akt Protein Sites  
4E-BP1 (Ser35) 4E-BP1 (Ser44) 4E-BP1 (Thr36) 4E-BP1 (Thr37)
4E-BP1 (Thr41) 4E-BP1 (Thr45) 4E-BP1 (Thr46) 4E-BP1 (Thr50)
4E-BP1 (Tyr34) 4E-BP1 (Tyr54) 4E-BP2 (Ser44) 4E-BP2 (Thr36)
4E-BP2 (Thr37) 4E-BP2 (Thr41) 4E-BP2 (Thr45) 4E-BP2 (Thr46)
4E-BP2 (Thr50) 4E-BP2 (Tyr34) 4E-BP2 (Tyr54) 4E-BP3 (Thr23)
4E-BP3 (Thr27) 4E-BP3 (Thr31) 4E-BP3 (Thr32) ACTB (Thr201)
ACTG1 (Thr201) Akt1 (Ser473) Akt1 (Thr305) Akt1 (Thr308)
Akt1 (Thr312) Akt1 (Tyr315) Akt2 (Ser474) Akt2 (Ser476)
Akt2 (Ser478) Akt2 (Thr309) Akt2 (Thr313) Akt2 (Tyr316)
Akt2 (Tyr475) Akt3 (Ser472) Akt3 (Ser474) Akt3 (Ser476)
Akt3 (Thr298) Akt3 (Thr305) Akt3 (Tyr473) ATR (Ser435)
ATR (Ser436) BAD (Ser71) BAD (Ser74) BAD (Ser75)
BAD (Ser91) BAD (Ser97) BAD (Ser99) BAD (Thr80)
BAD (Tyr76) CTNND1 iso3 (Ser168) CTNND1 iso3 (Thr147) CTNND1 iso3 (Thr149)
CTNND1 iso3 (Thr152) CTNND1 iso4 (Ser168) CTNND1 iso4 (Thr147) CTNND1 iso4 (Thr149)
CTNND1 iso4 (Thr152) CTNND1 (Ser168) CTNND1 (Thr147) CTNND1 (Thr149)
CTNND1 (Thr152) DNMT1 iso2 (Ser748) DNMT1 (Ser732) Dok1 (Tyr341)
Dok2 (Tyr299) eIF4H (Ser230) eIF4H (Thr217) eIF4H (Thr220)
EphA2 (Thr593) EphA2 (Thr771) EphA2 (Thr773) EphA2 (Thr774)
EphA2 (Tyr588) EphA2 (Tyr772) FAK iso2 (Ser211) FAK iso2 (Ser422)
FAK iso2 (Thr227) FAK iso2 (Tyr216) FAK iso2 (Tyr424) FAK iso2 (Tyr425)
FAK (Ser392) FAK (Ser574) FAK (Thr408) FAK (Tyr397)
FAK (Tyr576) FAK (Tyr577) FOXK1 (Thr273) FOXO1A (Ser256)
FOXO3A (Ser43) FOXO3A (Ser48) FOXO3A (Ser55) FOXO3A (Thr51)
Fyn iso2 (Tyr417) Fyn (Tyr420) GAPDH (Thr153) GOLGA3 (Ser1430)
GOLGA3 (Ser983) GOLGA4 (Ser40) GOLGA4 (Ser41) GOLGA4 (Thr39)
GOLGA4 (Thr43) GSK3A (Ser20) GSK3A (Ser21) GSK3A (Ser39)
GSK3A (Ser41) GSK3A (Thr19) GSK3A (Thr46) HGK iso5 (Ser908)
HGK iso5 (Thr187) HGK iso5 (Thr910) HGK iso7 (Ser463) HGK iso7 (Ser934)
HGK iso7 (Thr127) HGK iso7 (Thr936) HGK (Ser523) HGK (Ser913)
HGK (Thr187) HGK (Thr915) HRas (Tyr32) HRas (Tyr64)
IRS1 (Ser303) IRS1 (Ser307) IRS1 (Ser312) IRS1 (Ser315)
IRS1 (Ser323) IRS1 (Ser603) IRS1 (Ser604) IRS1 (Ser616)
IRS1 (Thr305) IRS1 (Thr309) IRS1 (Thr311) IRS1 (Thr608)
IRS1 (Tyr1179) IRS1 (Tyr612) IRS2 (Ser594) IRS2 (Tyr598)
KHSRP (Ser132) KRas iso2 (Tyr32) KRas iso2 (Tyr64) KRas (Tyr32)
KRas (Tyr64) lamin A/C iso2 (Ser404) lamin A/C iso2 (Ser406) lamin A/C (Ser404)
lamin A/C (Ser406) Lck (Tyr394) LOC647000 (Ser41) MEK1 (Ser218)
MEK1 (Ser222) MEK1 (Thr226) MEK2 (Ser222) MEK2 (Ser226)
MEK2 (Thr230) MINK iso4 (Thr187) MINK (Thr187) MST3 iso2 (Thr170)
MST3 iso2 (Thr172) MST3 iso2 (Thr178) MST3 iso2 (Thr182) MST3 (Thr182)
MST3 (Thr184) MST3 (Thr190) MST3 (Thr194) MST4 (Thr320)
MST4 (Thr327) mTOR (Ser2442) mTOR (Ser2448) mTOR (Ser2450)
mTOR (Ser2454) mTOR (Ser2478) mTOR (Ser2481) mTOR (Thr2444)
mTOR (Thr2446) mTOR (Thr2471) mTOR (Thr2473) mTOR (Thr2474)
mTOR (Tyr2449) MYPT1 (Ser802) MYPT1 (Ser910) MYPT1 (Thr453)
MYPT1 (Tyr446) MYPT1 (Tyr766) MYPT1 (Tyr901) MYPT1 (Tyr911)
NDRG1 (Ser344) NDRG1 (Ser352) NDRG1 (Ser354) NDRG1 (Ser357)
NDRG1 (Ser362) NDRG1 (Ser364) NDRG1 (Ser367) NDRG1 (Ser378)
NDRG1 (Ser384) NDRG1 (Ser389) NDRG1 (Ser393) NDRG1 (Thr346)
NDRG1 (Thr356) NDRG1 (Thr360) NDRG1 (Thr366) NDRG1 (Thr375)
NF-GMB iso2 (Ser134) NF-GMB iso2 (Tyr131) NF-GMB (Ser134) NF-GMB (Tyr131)
NF-κB p105 (Ser907) NRas (Tyr32) NRas (Tyr64) Nur77 (Ser351)
Nur77 (Ser360) PAK2 (Ser19) PAK2 (Ser20) PAK2 (Ser32)
PAK2 (Ser36) PAK2 (Ser42) PAK2 (Thr21) PAK2 (Thr25)
PAR-4 (Ser231) PAR-4 (Ser233) PAR-4 (Thr229) PAR-4 (Tyr177)
PDK1 iso2 (Ser114) PDK1 (Ser241) PDPK2 (Ser214) PIK3CA (Ser507)
PIK3CA (Ser509) PIK3R1 (Tyr467) PIK3R2 (Tyr464) PIK3R3 (Tyr199)
PIK3R5 (Ser507) PIK4CB iso2 (Ser256) PIK4CB (Ser256) PKA RI-α (Ser375)
PKCα (Thr494) PKCα (Thr497) PKCα (Tyr504) PKCβ iso2 (Thr498)
PKCβ iso2 (Thr500) PKCβ (Thr498) PKCβ (Thr500) PKCI (Thr412)
PKD2 (Ser375) PRAS40 (Ser203) PRAS40 (Thr266) PTEN (Ser385)
RANBP3 iso3 (Ser57) RANBP3 iso3 (Ser58) RANBP3 iso3 (Thr56) RANBP3 iso3 (Thr60)
RANBP3 (Ser125) RANBP3 (Ser126) RANBP3 (Thr124) RANBP3 (Thr128)
Raptor (Ser719) Raptor (Ser722) Rictor (Ser1320) RSK2 (Ser386)
S6 (Ser235) S6 (Ser236) S6 (Ser240) S6 (Ser242)
S6 (Ser244) S6 (Ser246) S6 (Ser247) S6 (Thr241)
SGK3 (Ser315) SGK3 (Thr318) Shb (Ser323) Shb (Tyr336)
SHIP-2 (Tyr886) Src (Tyr419) TUBA1A (Ser287) TUBA1B (Ser287)
TUBA3C (Ser287) TUBA3D (Ser287) TUBA3E (Ser287) TUBA4A (Ser287)
TUBB2A (Ser339) TUBB2B (Ser339) TUBB2C (Ser339) TUBB3 (Ser339)
TUBB4 (Ser339) TUBB6 (Ser339) TUBB (Ser339) XIAP (Ser123)
YB-1 (Ser102) YB-1 (Thr108) YB-1 (Tyr99) Yes (Tyr426)
YSK1 (Thr166) YSK1 (Thr168) YSK1 (Thr174) YSK1 (Thr178)