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Deciphering Epitranscriptomics: The importance of RNA modifications and RNA-binding proteins in disease

 

Epitranscriptomics refers to changes in an organism’s cells resulting from posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Uncovering the mechanisms underlying RNA modifications and RBP function are emerging frontiers in medicine that take the study of gene regulation a step beyond epigenetics.