• Li-Huei Tsai, Ph. D, Picower Professor of Neuroscience, Director of the Picower Institute for Learning and Memory, Massachusetts Institute of Technology
  • Raphael Rozenfeld, Ph.D, Development Scientist, Cell Signaling Technology

Deciphering the Molecular Pathology of Alzheimer’s Disease

Alzheimer’s disease presents stereotypical pathological features including the abundance of amyloid deposition and tauopathy. Affected brain regions also exhibit reactive astrogliosis, neuroinflammatory responses, and vascular pathology. Neuronal and synaptic loss is also evident. Various mouse lines have been created to investigate Alzheimer’s disease and most of the models exhibit a subset of the defining pathological features of the disease. In this webinar the speaker will discuss the use of Alzheimer’s disease transgenic mouse models to evaluate pathological features by both traditional immunohistochemistry and new tissue processing methods that enable whole- brain imaging. These immunolabeling methods further the investigation of molecular and neural circuit mechanisms of Alzheimer’s disease.

The Use of Highly Validated Antibodies to Study Neurodegenerative Disease

Cell Signaling Technology's (CST) mission to produce high quality and rigorously validated antibodies extends to our neuroscience products. We use a comprehensive approach, from the selection of targets that are the most relevant to the scientists' current and future research, to the establishment of models for careful validation of the antibodies, and the formulation of ready-to-use antibodies for various experimental procedures relevant to the targets. The neuroscience portfolio comprises antibodies to cell type, sub-cellular compartment, and cell state markers; antibodies against important neurotransmitters; and a growing product line in the field of neurodegenerative diseases, such as Alzheimer's Disease, Parkinson's, Huntington's, and ALS. Our cutting- edge antibody development technologies allow us to generate highly sensitive and specific antibodies to various amyloid-beta peptides, Tau phosphorylation sites, and other disease-research relevant proteins. In this presentation, we will discuss CST's existing and up-coming products that will help neuroscientists' research efforts.