Revision 4
Cell Signaling Technology

Orders: 877-616-CELL (2355) [email protected]

Support: 877-678-TECH (8324)

Web: [email protected]

3 Trask LaneDanversMassachusetts01923USA
For Research Use Only. Not for Use in Diagnostic Procedures.
Product Includes Product # Quantity Mol. Wt Isotype/Source
Basic FGF (E9S5A) Rabbit mAb 98658 20 µl 18, 22, 24 kDa Rabbit IgG
IGF-I (E6B7O) Rabbit mAb 73034 20 µl 9, 13, 18, 20 kDa Rabbit IgG
HGF β (D6S7D) XP® Rabbit mAb 52445 20 µl 35, 85 kDa Rabbit IgG
TGF-β (56E4) Rabbit mAb 3709 20 µl 12, 45-60 kDa Rabbit 
HBEGF (E5L5T) Rabbit mAb 27450 20 µl 18, 21, 27 kDa Rabbit IgG
MIF (E7T1W) Rabbit mAb 87501 20 µl 12 kDa Rabbit IgG
EREG (D4O5I) Rabbit mAb 12048 20 µl 17,19, 30 kDa Rabbit IgG
Angiopoietin-2 (D200) Antibody 50697 20 µl 68, 70 kDa Rabbit 
Anti-rabbit IgG, HRP-linked Antibody 7074 100 µl Goat 
VEGF-A (E9X8Q) Rabbit mAb 50661 20 µl 16, 20, 23, 26 kDa Rabbit IgG

Please visit for individual component applications, species cross-reactivity, dilutions, protocols, and additional product information.


The Cancer-associated Growth Factor Antibody Sampler Kit provides an economical means of detecting selected growth factors that have been shown to influence tumor development. The kit includes enough antibodies to perform two western blot experiments with each primary antibody.


Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibodies.


The tumor microenvironment (TME) is composed of a heterogenous mixture of tumor cells, blood vessels, fibroblasts, stromal cells, infiltrating immune cells, and extracellular matrix (ECM) components, whose collective interactions play important roles in tumor development (1). Cells in the TME secrete a variety of bioactive molecules, including growth factors, cytokines, ECM proteins, and proteases (e.g., MMPs), many of which play critical roles in regulating growth and development of the tumor (2,3). Growth factors play particularly important roles in the TME, serving as cellular messengers that trigger activation or suppression of signaling pathways that govern tumor development, either directly via the tumor cells, or indirectly by way of effects on the TME. Binding of growth factors to their cognate receptors leads to activation of intracellular signaling pathways, resulting in changes in the expression of target genes that regulate cell behavior. Many growth factors (e.g., IGFs, HGFs, FGFs, HBEGF, EREG) are known to promote tumor development by way of direct effects on tumor cells; other growth factors can affect tumor development indirectly, through effects in the TME that influence tumor angiogenesis (e.g., VEGFs, angiopoietins), ECM deposition (TGF-β), or immune cell signaling (e.g., TGF-β, HBEGF, MIF) (4). The diverse and complex role played by growth factors in promoting tumorigenesis makes them important therapeutic targets in oncology, while elucidating the functions of specific growth factors in the context of tumor development remains an active area of cancer research (5).

  1. Quail, D.F. and Joyce, J.A. (2013) Nat Med 19, 1423-37.
  2. Wortzel, I. et al. (2019) Dev Cell 49, 347-360.
  3. Massagué, J. and Obenauf, A.C. (2016) Nature 529, 298-306.
  4. Penticuff, J.C. et al. (2019) Nat Rev Urol 16, 318-328.
  5. Steeg, P.S. (2016) Nat Rev Cancer 16, 201-18.

Background References

    Trademarks and Patents

    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    XP is a registered trademark of Cell Signaling Technology, Inc.
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    Limited Uses

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    Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.