Revision 8

#26768Store at -20C

1 Kit

(4 x 20 microliters)

Cell Signaling Technology

Orders: 877-616-CELL (2355) [email protected]

Support: 877-678-TECH (8324)

Web: [email protected]

3 Trask LaneDanversMassachusetts01923USA
For Research Use Only. Not for Use in Diagnostic Procedures.
Product Includes Product # Quantity Mol. Wt Isotype/Source
PARP (46D11) Rabbit mAb 9532 20 µl 116, 89 kDa Rabbit 
AIF (D39D2) XP® Rabbit mAb 5318 20 µl 67 kDa Rabbit IgG
MIF (E8S8H) Rabbit mAb 75038 20 µl 12 kDa Rabbit IgG
Anti-rabbit IgG, HRP-linked Antibody 7074 100 µl Goat 
Poly/Mono-ADP Ribose (D9P7Z) Rabbit mAb 89190 20 µl Rabbit IgG

Please visit for individual component applications, species cross-reactivity, dilutions, protocols, and additional product information.


The Parthanatos Antibody Sampler Kit provides an economical means of detecting the activation of parthanatos. The kit includes enough antibodies to perform two western blot experiments with each primary antibody.


Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibodies.


Parthanatos is a form of regulated cell death that follows a multistep cascade and is triggered by the accumulation of poly (ADP-ribose) (PAR). When PAR polymerase-1 (PARP-1) is overactivated under certain conditions, excessive PAR is produced and binds to apoptosis-inducing factor (AIF). As a result, AIF is released from the mitochondria and forms a complex with macrophage migration inhibitory factor (MIF). Subsequently, the AIF/MIF complex is translocated to the nucleus where MIF cleaves genomic DNA into large fragments, and cell death follows (1-3). Studies have found that parthanatos is involved in the pathogenesis of many diseases, particularly neurodegenerative disorders, such as Alzheimer's disease, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) (4-7).

  1. Fatokun, A.A. et al. (2014) Br J Pharmacol 171, 2000-16.
  2. Wang, Y. et al. (2016) Science 354, aad6872. doi: 10.1126/science.aad6872.
  3. Liu, L. et al. (2022) Cell Mol Life Sci 79, 60.
  4. Park, H. et al. (2020) Int Rev Cell Mol Biol 353, 1-29.
  5. Wang, X. and Ge, P. (2020) Neuroscience 449, 241-250.
  6. Zhou, Y. et al. (2021) Pharmacol Res 163, 105299.
  7. Thapa, K. et al. (2021) Life Sci 267, 118975.

Background References

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