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We recommend the following alternatives

W IP       ChIP H M R Mk
W IP         H M R Mk
68 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

NRF1 Antibody recognizes endogenous levels of total NRF1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu167 of human NRF1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Nuclear respiratory factor 1 (NRF1) was identified as a transcription activator for the gene encoding cytochrome c (1). It was later found to play a role in the nuclear control of mitochondrial function (1). PGC-1 induces the expression of NRF1 and NRF2 (2). NRF1, along with the coactivator PGC-1, stimulates the promoter of mitochondrial transcription factor A, which regulates mitochondrial biogenensis and function (2).

1.  Virbasius, C.A. et al. (1993) Genes Dev 7, 2431-45.

2.  Wu, Z. et al. (1999) Cell 98, 115-24.

Entrez-Gene Id 4899
Swiss-Prot Acc. Q16656

For Research Use Only. Not For Use In Diagnostic Procedures.
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NRF1 Antibody