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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

hnRNP C1/C2 Antibody recognizes endogenous levels of total hnRNP C1/C2 protein. This antibody does not cross-react with other hnRNPCL1 or RALY proteins.

Species predicted to react based on 100% sequence homology: Hamster, Xenopus, Bovine, Dog, Pig, Guinea Pig, Horse

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human hnRNP C1/C2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2) has multiple biological functions including transcriptional regulation, DNA repair, and RNA processing. hnRNP C1/C2 acts as a ‘molecular ruler’ in the mRNA processing pathway, committing nascent transcripts from the chromatin template to the mRNA export pathway once the nascent transcript becomes longer than 200-300 nucleotides (1). hnRNP C1/C2 associates with SWI/SNF and NurD family members to form the locus control region (LCR)-associated remodeling complex (LARC), which binds to β-globin gene promoter to prevent transcriptional silencing. Studies indicate that without hnRNP C1/C2, LARC does not associate with its target DNA sequence (2,3). hnRNP C1/C2 and other hnRNP family members interact with DNA damage response (DDR) proteins (4). hnRNP proteins regulate double stranded break (DSB) repair by promoting either homologous recombination (HR) or non-homologous end joining (NHEJ) (4). hnRNP C1/C2 downregulates the expression of miR-21, which leads to the increased expression of programmed cell death 4 (PDCD4) protein in glioblastoma multiforme (GBM) (5). Research studies have shown that silencing of hnRNP C1/C2 renders GBM cells more susceptible to apoptosis (5).

1.  McCloskey, A. et al. (2012) Science 335, 1643-6.

2.  Huang, L. et al. (2011) Mol Cell Biol 31, 3472-84.

3.  Mahajan, M.C. et al. (2005) Proc Natl Acad Sci U S A 102, 15012-7.

4.  Haley, B. et al. (2009) Int J Radiat Biol 85, 643-55.

5.  Park, Y.M. et al. (2012) Mol Cell Biol 32, 4237-44.

Entrez-Gene Id 3183
Swiss-Prot Acc. P07910

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

hnRNP C1/C2 Antibody