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EDC3 Antibody #12469
This product is discontinued
Gallery: EDC3 Antibody #12469
EDC3 Antibody recognizes endogenous levels of total EDC3 protein.
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly322 of human EDC3 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Enhancer of mRNA decapping 3 (EDC3) was originally identified from Saccharomyces cerevisiae as a protein essential to mRNA decapping prior to 5’-3’ mRNA degradation (1). In human cells, EDC3 is found within cytoplasmic processing (P) bodies as part of complexes that include DCP1, DCP2, EDC4/Ge-1, and DDX6/RCK (2). EDC3 and DCP2 interact with TTP, an activator of AU-rich-element (ARE)-mediated decay pathway, to promote decapping and degradation of ARE mRNA (2). In addition, research studies indicate that EDC3 may play a role in the premature termination of RNA polymerase II transcription (3).
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